POMC Neurons: Feeding, Energy Metabolism, and Beyond.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1286-1_2
Abstract: The central melanocortin system is a well-established neuronal pathway involved in regulating energy metabolism. Pro-opiomelanocortin (POMC) neurons, agouti gene-related protein (AgRP) neurons, and their downstream cells expressing the melanocortin-3 (MC3R) and melanocortin-4 receptors (MC4R) are… read more here.
Keywords: feeding energy; energy; pomc neurons; neurons feeding ... See more keywords
Role of TRH/UCN3 neurons of the perifornical area/bed nucleus of stria terminalis region in the regulation of the anorexigenic POMC neurons of the arcuate nucleus in male mice and rats
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1553-5
Abstract: Two anorexigenic peptides, thyrotropin-releasing hormone (TRH) and urocortin 3 (UCN3), are co-expressed in a continuous neuronal group that extends from the perifornical area to the bed nucleus of stria terminalis, raising the possibility that this… read more here.
Keywords: perifornical area; pomc neurons; trh ucn3; ucn3 neurons ... See more keywords
Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1052-6
Abstract: Hypothalamic proopiomelanocortin (POMC) neurons are important players in the regulation of energy homeostasis; we previously demonstrated that environmental stimulation excites arcuate nucleus circuits to undergo plastic remodeling, leading to altered ratio between excitatory and inhibitory… read more here.
Keywords: mtor signaling; pomc neurons; activity hypothalamic; mtor ... See more keywords
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.034
Abstract: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons. Here, we demonstrate that inactivation of apoptosis-inducing factor (AIF) in POMC neurons mildly impairs mitochondrial respiration and decreases firing… read more here.
Keywords: pomc neurons; fatty acid; pomc; obesity ... See more keywords
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.05.010
Abstract: Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control. However, the precise mechanisms underlying nutrient sensing in POMC neurons remain incompletely understood. We show that mitochondrial dynamics… read more here.
Keywords: dynamics mediated; pomc neurons; glucose sensing; insulin release ... See more keywords
Growth hormone/STAT5 signaling in proopiomelanocortin neurons regulates glucoprivic hyperphagia
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110574
Abstract: Several hypothalamic neuronal populations are directly responsive to growth hormone (GH) and central GH action regulates glucose and energy homeostasis. However, the potential role of GH signaling in proopiomelanocortin (POMC) neurons has not been studied… read more here.
Keywords: glucoprivic hyperphagia; pomc neurons; stat5; growth hormone ... See more keywords
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.02.007
Abstract: Objective Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. Methods Using single cell RNA sequencing,… read more here.
Keywords: single cell; neurons revealed; pomc neurons; cell rna ... See more keywords
Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.07.008
Abstract: Objective The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, stimulates insulin secretion and efficiently suppresses food intake to reduce body weight. As such, liraglutide is growing in popularity in the treatment of diabetes and chronic… read more here.
Keywords: pomc neurons; npy agrp; pomc npy; agrp neurons ... See more keywords
Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.100994
Abstract: Objective Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established. Here, we… read more here.
Keywords: pomc neurons; sirt6; energy metabolism; energy ... See more keywords
Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1802237115
Abstract: Significance The interplay between the anorexigenic and orexigenic neurons in the arcuate nucleus that contributes to the control of feeding remains elusive. Using optogenetic stimulation, we show that activation of POMC neurons rapidly inhibits feeding… read more here.
Keywords: control feeding; pomc neurons; pomc; orexigenic neurons ... See more keywords
A critical update on the leptin‐melanocortin system
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15765
Abstract: The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that provided new opportunities to better understand the central control of energy balance and glucose metabolism. Rapidly, a prevalent model… read more here.
Keywords: melanocortin system; leptin; leptin melanocortin; pomc neurons ... See more keywords