Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors.
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DOI: 10.1016/j.ejmech.2016.10.003
Abstract: FGF receptors (FGFRs) are tyrosine kinases that are overexpressed in diverse tumors by genetic alterations such as gene amplifications, somatic mutations and translocations. Owing to this characteristic, FGFRs are attractive targets for cancer treatment. It… read more here.
Keywords: novel ponatinib; activity; discovery novel; ponatinib analogues ... See more keywords
Synthesis of ponatinib analogues as novel inhibitors of leukemia stem cells.
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DOI: 10.4155/fmc-2022-0038
Abstract: Aim: To synthesize new analogues of ponatinib and evaluate anti-leukemia cells and cytotoxicity. Methodology & results: The inhibitory activity of compounds 13a and 13c against K562 and HL60 cells was comparable to that of ponatinib… read more here.
Keywords: novel inhibitors; analogues novel; ponatinib analogues; synthesis ponatinib ... See more keywords