Signal Transduction in Diffuse Intrinsic Pontine Glioma
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DOI: 10.1002/pmic.201800479
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an untreatable, heterogeneous high‐grade glioma (HGG) of the brainstem. This highly aggressive cancer affects mostly young children and is uniformly fatal. Genomic studies show that DIPG is driven by… read more here.
Keywords: diffuse intrinsic; intrinsic pontine; glioma; pontine glioma ... See more keywords
Reirradiation for diffuse intrinsic pontine glioma: a systematic review and meta-analysis
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DOI: 10.1007/s00381-019-04118-y
Abstract: BackgroundDiffuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with dismal prognosis despite initial radiation therapy (RT). The clinical consequences of attempting reirradiation (reRT) in these patients to alleviate both symptomatology and improve prognosis… read more here.
Keywords: review meta; analysis; systematic review; intrinsic pontine ... See more keywords
International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
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DOI: 10.1007/s11060-018-03038-2
Abstract: PurposeDiffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlying biology, and… read more here.
Keywords: xenograft models; intrinsic pontine; pontine glioma; development ... See more keywords
Retrospective study of diffuse intrinsic pontine glioma in the Belgian population: a 25 year experience
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DOI: 10.1007/s11060-021-03766-y
Abstract: Diffuse intrinsic pontine glioma is a rare disease with a high mortality. Our primary aim was to determine the incidence of this disease in Belgium. Secondly, we wanted to compare the treatment approach of Belgian… read more here.
Keywords: diffuse intrinsic; intrinsic pontine; oncology; pontine glioma ... See more keywords
Diffuse Intrinsic Pontine Glioma: From Diagnosis to Next-Generation Clinical Trials
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DOI: 10.1007/s11940-019-0577-y
Abstract: This review of diffuse intrinsic pontine glioma (DIPG) provides clinical background, a systematic approach to diagnosis and initial care, and synthesizes historical, modern, and future directions for treatment. We present evidence supporting neurosurgical biopsy, early… read more here.
Keywords: diffuse intrinsic; glioma; intrinsic pontine; clinical trials ... See more keywords
Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.043
Abstract: Background Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain cancer without cure. Seeking therapeutic strategies is still a major challenge in DIPG research. Previous study has shown that dysregulation of G1/S… read more here.
Keywords: diffuse intrinsic; treatment; intrinsic pontine; dipg ... See more keywords
An atypical presentation of diffuse midline pontine glioma in a middle age patient: Case report
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DOI: 10.1016/j.jocn.2019.08.096
Abstract: INTRODUCTION Diffuse midline glioma is a newly WHO defined entity (grade IV) (Louis et al., 2016) which includes diffuse intrinsic pontine glioma (DIPG) reported in pediatric population and, occasionally, in young adults. Here, we present… read more here.
Keywords: pontine glioma; diffuse midline; glioma; case ... See more keywords
Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied nano materials"
DOI: 10.1021/acsanm.0c02297
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used… read more here.
Keywords: diffuse intrinsic; focused ultrasound; 64cu cuncs; delivery ... See more keywords
A Combined Approach of Convection-Enhanced Delivery of Peptide Nanofiber Reservoir to Prolong Delivery of DM1 for Diffuse Intrinsic Pontine Glioma Treatment.
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DOI: 10.1093/neuonc/noaa101
Abstract: BACKGROUND Diffuse intrinsic pontine glioma (DIPG) is a highly lethal malignancy that occurs predominantly in children. DIPG is inoperable and post-diagnosis survival is less than 1 year, as conventional chemotherapy is ineffective. The intact blood… read more here.
Keywords: diffuse intrinsic; dm1; glioma; delivery ... See more keywords
INNV-07. THE ROLE OF BIOPSY IN MOLECULAR DIAGNOSIS OF DIFFUSE INTRINSIC PONTINE GLIOMA PATIENTS
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DOI: 10.1093/neuonc/noaa215.491
Abstract: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and fatal pediatric brain tumor. Due to its difficult anatomic location and infiltrative nature, DIPGs are not surgically resectable and more than 90% of children die within… read more here.
Keywords: diffuse intrinsic; biopsy; diagnosis; treatment ... See more keywords
SURG-24. REPEAT CONVECTION-ENHANCED DELIVERY FOR DIFFUSE INTRINSIC PONTINE GLIOMA
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DOI: 10.1093/neuonc/noaa215.871
Abstract: While the safety and efficacy of convection-enhanced delivery (CED) have been studied in patients receiving single dose drug infusions, agents for oncologic therapy require repeated or chronic infusions to maintain therapeutic concentrations. Repeat/chronic CED infusions… read more here.
Keywords: diffuse intrinsic; infusion; pontine glioma; intrinsic pontine ... See more keywords