Re‐irradiation of recurrent gliomas: pooled analysis and validation of an established prognostic score—report of the Radiation Oncology Group (ROG) of the German Cancer Consortium (DKTK)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1425
Abstract: The heterogeneity of high‐grade glioma recurrences remains an ongoing challenge for the interdisciplinary neurooncology team. Response to re‐irradiation (re‐RT) is heterogeneous, and survival data depend on prognostic factors such as tumor volume, primary histology, age,… read more here.
Keywords: prognostic score; histology; oncology; pooled analysis ... See more keywords
Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3298
Abstract: We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of four randomized… read more here.
Keywords: analysis four; four randomized; overall survival; pooled analysis ... See more keywords
Direct Oral Anticoagulation versus Warfarin in Left Ventricular Thrombus: Pooled Analysis of Randomized Controlled Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.2267
Abstract: Patients with impaired left ventricular (LV) function can develop LV thrombus, a potentially life-threatening condition due to risk of stroke and embolization. Conventional treatment with vitamin K antagonists (VKA; e.g., warfarin) puts patients at risk… read more here.
Keywords: randomized controlled; controlled trials; direct oral; thrombus ... See more keywords
A Pooled Analysis From Phase 2b and 3 Studies in Japan of Istradefylline in Parkinson's Disease
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DOI: 10.1002/mds.28095
Abstract: Characterization of patient factors associated with istradefylline efficacy may facilitate personally optimized treatment. read more here.
Keywords: japan istradefylline; analysis phase; istradefylline parkinson; studies japan ... See more keywords
Pharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2217-3
Abstract: PurposeEmerging data on selumetinib, a MEK1/2 inhibitor in clinical development, suggest a possible difference in pharmacokinetics (PK) between Japanese and Western patients. This pooled analysis sought to assess the effect of ethnicity on selumetinib exposure… read more here.
Keywords: selumetinib; analysis; mek1 inhibitor; asian subjects ... See more keywords
Targeted Therapeutics for Transthyretin amyloid cardiomyopathy: Time to Move Forward
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.080
Abstract: Introduction Deposition of wild type or mutant transthyretin (TTR) amyloid fibrils causes TTR cardiac amyloidosis (ATTR-CA). Targeted therapeutics (TT) for ATTR-CA include TTR stabilizers (tafamidis, dilfunisal) and oligonucleotide drugs (Revusiran, Patisiran and Inotersen).TTR stabilizers prevent… read more here.
Keywords: targeted therapeutics; patients attr; therapeutics transthyretin; cause mortality ... See more keywords
Pooled Analysis of external-beam RADiotherapy parameters in phase II and phase III trials in radiochemotherapy in Anal Cancer (PARADAC).
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2019.08.022
Abstract: PURPOSE Concomitant external-beam radiochemotherapy (5-fluorouracil-mitomycin C) has become the standard of care in anal cancer since the '90s. A pooled analysis of individual patient data from 7 major trials was performed quantifying the effect of… read more here.
Keywords: cancer; pooled analysis; external beam; anal cancer ... See more keywords
Efficacy and safety of dupilumab monotherapy in adults with moderate-to-severe atopic dermatitis: a pooled analysis of two phase 3 randomized trials (LIBERTY AD SOLO 1 and LIBERTY AD SOLO 2).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.02.002
Abstract: BACKGROUND Two phase 3 trials with identical design, LIBERTY AD SOLO 1 (NCT02277743) and LIBERTY AD SOLO 2 (NCT02277769), confirmed dupilumab efficacy and safety versus placebo in adults with moderate-to-severe atopic dermatitis (AD). OBJECTIVES To… read more here.
Keywords: liberty solo; moderate severe; safety; adults moderate ... See more keywords
Clinical, neuroradiological, diagnostic and prognostic profile of autoimmune glial fibrillary acidic protein astrocytopathy: A pooled analysis of 324 cases from published data and a single-center retrospective study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577718
Abstract: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently defined autoimmune meningoencephalomyelitis, associated with GFAP-IgG antibody. A pooled analysis of 324 cases from published literature and a retrospective single-center study were performed, firstly reveals… read more here.
Keywords: fibrillary acidic; analysis 324; acidic protein; glial fibrillary ... See more keywords
Clinical characteristics and treatment of clavicular osteomyelitis: a systematic review with pooled analysis of 294 reported cases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of shoulder and elbow surgery"
DOI: 10.1016/j.jse.2018.11.071
Abstract: BACKGROUND It is usually difficult to diagnose clavicular osteomyelitis (OM), and treatment is delayed because of its rarity. This study aimed to summarize clinical characteristics and treatment of this disease. METHODS We searched the PubMed… read more here.
Keywords: treatment; characteristics treatment; clavicular osteomyelitis; rate ... See more keywords
Interpretation of results of pooled analysis of individual patient data – Authors' reply
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DOI: 10.1016/s0140-6736(18)31779-3
Abstract: We thank Nick Freemantle and Domenico Pagano, and Peter Juni and colleagues for their comments on our Article on mortality after coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI), in which we identified… read more here.
Keywords: left main; interpretation results; disease; results pooled ... See more keywords