Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.
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DOI: 10.1007/s11095-021-03076-y
Abstract: PURPOSE A dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical animal species to predict high urinary excretion, and corresponding poor metabolism, in humans.… read more here.
Keywords: excretion; metabolism humans; preclinical animal; drug ... See more keywords