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   Articles with "poorly soluble" as a keyword



Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions.

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recommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"

DOI: 10.1002/wnan.1859

Abstract: Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor… read more here.

Keywords: poorly soluble; technology; delivery poorly; soluble drugs ... See more keywords

Organogel Nanoparticles as a New Way to Improve Oral Bioavailability of Poorly Soluble Compounds

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recommendations! Published in 2020 at "Pharmaceutical Research"

DOI: 10.1007/s11095-020-02808-w

Abstract: The aim of the study was to evaluate organogel nanoparticles as a lipophilic vehicle to increase the oral bioavailability of poorly soluble compounds. Efavirenz (EFV), a Biopharmaceutical Classification System (BCS) Class II, was used as… read more here.

Keywords: oral bioavailability; poorly soluble; bioavailability; bioavailability poorly ... See more keywords

Enhanced pulmonary absorption of poorly soluble itraconazole by micronized cocrystal dry powder formulations

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recommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"

DOI: 10.1016/j.ejpb.2017.02.013

Abstract: &NA; Micronized cocrystal powders and amorphous spray‐dried formulations were prepared and evaluated in vivo and in vitro as pulmonary absorption enhancement formulations of poorly soluble itraconazole (ITZ). ITZ cocrystals with succinic acid (SA) or l‐tartaric… read more here.

Keywords: absorption; poorly soluble; micronized cocrystal; pulmonary absorption ... See more keywords
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Spray drying of poorly soluble drugs from aqueous arginine solution.

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recommendations! Published in 2017 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2017.09.015

Abstract: Co-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behavior of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods, or with methods… read more here.

Keywords: poorly soluble; spray drying; drying poorly; soluble drugs ... See more keywords

smartPearls – Novel physically stable amorphous delivery system for poorly soluble dermal actives

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recommendations! Published in 2019 at "International Journal of Pharmaceutics"

DOI: 10.1016/j.ijpharm.2018.11.018

Abstract: Graphical abstract Figure. No caption available. Abstract Dermally applied poorly soluble actives whether in cosmetics or pharmaceuticals show insufficient skin penetration. Especially actives being insoluble in both phases of dermal vehicles, i.e. water and oil… read more here.

Keywords: poorly soluble; smartpearls novel; soluble actives; delivery ... See more keywords

Improvement of dissolution of poorly soluble glimepiride by loading on two types of mesoporous silica carriers

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recommendations! Published in 2019 at "Journal of Solid State Chemistry"

DOI: 10.1016/j.jssc.2018.12.062

Abstract: Abstract The aim of the present study was to evaluate the potential of MCM-41 and HMS mesoporous silica particles as efficient carriers for poorly soluble drug, such as glimepiride (BCS, class II). In vitro release… read more here.

Keywords: drug; improvement dissolution; mesoporous silica; poorly soluble ... See more keywords

Preparation of novel optimum liquisolid compacts via incorporating water granulation process to enhance the powder characterizations and dissolution behavior of a poorly soluble drug: Norfloxacin

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recommendations! Published in 2019 at "Powder Technology"

DOI: 10.1016/j.powtec.2019.05.071

Abstract: The aim of this work is to investigate the addition of wet granulation technique into liquisolid process in order to enhance the characterizations of liquisolid compacts, such as flowability, compressibility and the percentage of drug… read more here.

Keywords: water; poorly soluble; drug; process ... See more keywords

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake.

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recommendations! Published in 2018 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.7b00967

Abstract: The majority of the currently used and developed anti-infectives are poorly water-soluble molecules. The poor solubility might lead to limited bioavailability and pharmacological action of the drug. Novel pharmaceutical materials have thus been designed to… read more here.

Keywords: poorly soluble; delivery; anti infective; drug ... See more keywords

Unraveling the Impact of Stabilizers on Nanocrystal Preparation and Oral Absorption: A Case Study of Poorly Soluble Andrographolide.

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recommendations! Published in 2024 at "Nano letters"

DOI: 10.1021/acs.nanolett.4c05230

Abstract: Drug nanocrystal engineering is an attractive pharmaceutical approach to enhancing the oral bioavailability of poorly soluble drugs. The mechanism of drug nanocrystal stabilization, however, is unclear. Here we developed andrographolide nanocrystals (AG-NCs) with various nonionic… read more here.

Keywords: preparation; pluronic f127; poorly soluble; oral absorption ... See more keywords

Cyclodextrin metal–organic framework@SiO2 nanocomposites for poorly soluble drug loading and release

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recommendations! Published in 2024 at "RSC Advances"

DOI: 10.1039/d4ra04935g

Abstract: The development of non-toxic drug carrier materials with high loading capacity, sustained release properties, stability, and biocompatibility holds significant medical value and potential for loading and releasing poorly soluble drugs. In this study, we synthesized… read more here.

Keywords: spectroscopy; drug loading; mof sio2; release ... See more keywords

Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs

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recommendations! Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aav9784

Abstract: Computer-assisted strategy for drug delivery leads to discovery of polymeric micelle formulations for poorly soluble drugs. Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable… read more here.

Keywords: poorly soluble; discovery polymeric; soluble drugs; drug ... See more keywords