Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1859
Abstract: Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor… read more here.
Keywords: poorly soluble; technology; delivery poorly; soluble drugs ... See more keywords
Organogel Nanoparticles as a New Way to Improve Oral Bioavailability of Poorly Soluble Compounds
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-020-02808-w
Abstract: The aim of the study was to evaluate organogel nanoparticles as a lipophilic vehicle to increase the oral bioavailability of poorly soluble compounds. Efavirenz (EFV), a Biopharmaceutical Classification System (BCS) Class II, was used as… read more here.
Keywords: oral bioavailability; poorly soluble; bioavailability; bioavailability poorly ... See more keywords
Enhanced pulmonary absorption of poorly soluble itraconazole by micronized cocrystal dry powder formulations
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.02.013
Abstract: &NA; Micronized cocrystal powders and amorphous spray‐dried formulations were prepared and evaluated in vivo and in vitro as pulmonary absorption enhancement formulations of poorly soluble itraconazole (ITZ). ITZ cocrystals with succinic acid (SA) or l‐tartaric… read more here.
Keywords: absorption; poorly soluble; micronized cocrystal; pulmonary absorption ... See more keywords
Spray drying of poorly soluble drugs from aqueous arginine solution.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.015
Abstract: Co-amorphous drug-amino acid mixtures have shown potential for improving the solid-state stability and dissolution behavior of amorphous drugs. In previous studies, however these mixtures have been produced mainly with small-scale preparation methods, or with methods… read more here.
Keywords: poorly soluble; spray drying; drying poorly; soluble drugs ... See more keywords
smartPearls – Novel physically stable amorphous delivery system for poorly soluble dermal actives
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.018
Abstract: Graphical abstract Figure. No caption available. Abstract Dermally applied poorly soluble actives whether in cosmetics or pharmaceuticals show insufficient skin penetration. Especially actives being insoluble in both phases of dermal vehicles, i.e. water and oil… read more here.
Keywords: poorly soluble; smartpearls novel; soluble actives; delivery ... See more keywords
Improvement of dissolution of poorly soluble glimepiride by loading on two types of mesoporous silica carriers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2018.12.062
Abstract: Abstract The aim of the present study was to evaluate the potential of MCM-41 and HMS mesoporous silica particles as efficient carriers for poorly soluble drug, such as glimepiride (BCS, class II). In vitro release… read more here.
Keywords: drug; improvement dissolution; mesoporous silica; poorly soluble ... See more keywords
Preparation of novel optimum liquisolid compacts via incorporating water granulation process to enhance the powder characterizations and dissolution behavior of a poorly soluble drug: Norfloxacin
Sign Up to like & getrecommendations! Published in 2019 at "Powder Technology"
DOI: 10.1016/j.powtec.2019.05.071
Abstract: The aim of this work is to investigate the addition of wet granulation technique into liquisolid process in order to enhance the characterizations of liquisolid compacts, such as flowability, compressibility and the percentage of drug… read more here.
Keywords: water; poorly soluble; drug; process ... See more keywords
Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00967
Abstract: The majority of the currently used and developed anti-infectives are poorly water-soluble molecules. The poor solubility might lead to limited bioavailability and pharmacological action of the drug. Novel pharmaceutical materials have thus been designed to… read more here.
Keywords: poorly soluble; delivery; anti infective; drug ... See more keywords
Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav9784
Abstract: Computer-assisted strategy for drug delivery leads to discovery of polymeric micelle formulations for poorly soluble drugs. Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable… read more here.
Keywords: poorly soluble; discovery polymeric; soluble drugs; drug ... See more keywords
Disproportionation of manganese(II) (1-hydroxyethylidene) diphosphonate in reaction with 2-aminoethanol
Sign Up to like & getrecommendations! Published in 2017 at "Doklady Chemistry"
DOI: 10.1134/s0012500817080092
Abstract: Reaction of poorly soluble manganese(II) bis(1-hydroxyethylidene)diphosphonate tetrahydrate Mn(H3L)2 · 4H2O with 2-aminoethanol H2NCH2CH2OH in an aqueous solution on heating to 70–80°C causes the initial formation of soluble tris(2-hydroxyethanaminium) manganese(II) bis(1-hydroxyethylidene) diphosphonate Mn(H3L)2 · 3H2NCH2CH2OH ·… read more here.
Keywords: poorly soluble; hydroxyethylidene diphosphonate; reaction; manganese hydroxyethylidene ... See more keywords
Preparation, Characterization and Antioxidant Evaluation of Poorly Soluble Polyphenol-Loaded Nanoparticles for Cataract Treatment
Sign Up to like & getrecommendations! Published in 2019 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-019-1379-y
Abstract: Cataract, one of the leading causes of blindness worldwide, is a condition in which complete or partial opacity develops in the lens of the eyes, thereby impairing vision. This study aimed to examine the potential… read more here.
Keywords: polyphenol loaded; poorly soluble; treatment; loaded nanoparticles ... See more keywords