Multifunctional Block Copolymers for Simultaneous Solubilization of Poorly Water‐Soluble Cholesterol and Hydroxyapatite Crystals
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201808331
Abstract: The solubilization of targeted compounds represents key criteria in the sophisticated field of medical chemistry but also in technical applications like scale removal. Especially, the simultaneous dissolution of two chemically different compounds remains challenging. Herein,… read more here.
Keywords: simultaneous dissolution; water soluble; cholesterol; poorly water ... See more keywords
Lipid nanoparticles for administration of poorly water soluble neuroactive drugs
Sign Up to like & getrecommendations! Published in 2017 at "Biomedical Microdevices"
DOI: 10.1007/s10544-017-0188-x
Abstract: This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e. dimethylfumarate, retinyl palmitate, progesterone and… read more here.
Keywords: administration; water soluble; poorly water; lipid nanoparticles ... See more keywords
Solubilisation behaviour of poorly water‐soluble drugs during digestion of solid SMEDDS
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.07.006
Abstract: ABSTRACT Lipid based‐formulations can enhance the bioavailability of poorly water‐soluble lipophilic drugs through enhanced solubilisation of drugs in the gastrointestinal (GI) tract during digestion. This study investigates the solubilisation behaviour of poorly water‐soluble drugs upon… read more here.
Keywords: solubilisation behaviour; solubilisation; digestion; water soluble ... See more keywords
Montmorillonite-lipid hybrid carriers for ionizable and neutral poorly water-soluble drugs: Formulation, characterization and in vitro lipolysis studies.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.063
Abstract: Lipid-based formulations (LBFs) are a popular strategy for enhancing the gastrointestinal solubilization and absorption of poorly water-soluble drugs. In light of this, montmorillonite-lipid hybrid (MLH) particles, composed of medium-chain triglycerides, lecithin and montmorillonite clay platelets,… read more here.
Keywords: soluble drugs; water soluble; lipid hybrid; poorly water ... See more keywords
Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water‐soluble drugs
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.03.038
Abstract: &NA; Amorphous solid dispersions (ASDs) are a promising formulation strategy to increase both the apparent aqueous solubility and bioavailability of poorly water‐soluble drugs. Upon dissolution under nonsink conditions, ASDs can generate highly supersaturated drug solutions… read more here.
Keywords: phase; water; soluble drugs; water soluble ... See more keywords
Use of calcium carbonate as an excipient for release of poorly water soluble drugs: the case of carbamazepine.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119860
Abstract: Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the… read more here.
Keywords: carbamazepine; water soluble; drug; poorly water ... See more keywords
Impact of altered hydrophobicity and reduced agglomeration on dissolution of micronized poorly water-soluble drug powders after dry coating.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120853
Abstract: The impact of dry coating with hydrophobic or hydrophilic nano-silica at 25-100% surface area coverage on dissolution of micronized poorly water-soluble drugs was investigated by examining their agglomeration and surface hydrophobicity. Ibuprofen (20 µm and… read more here.
Keywords: surface; dry coating; drug; poorly water ... See more keywords
Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.04.006
Abstract: Although strip films are a promising platform for delivery of poorly water-soluble drug particles via slurry casting, the effect of critical material attributes, for example, superdisintegrants (SDIs) on critical quality attributes, including film disintegration time… read more here.
Keywords: water soluble; poorly water; soluble drug; film ... See more keywords
The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.04.001
Abstract: A number of drugs that are currently on the market, as well as new candidates for drugs, are poorly water soluble. Because of this, a need exists to develop drug formulations that will permit the… read more here.
Keywords: mito porter; poorly water; coq10 mito; porter ... See more keywords
Phase Behavior and Crystallization Kinetics of a Poorly Water-Soluble Weakly Basic Drug as a Function of Supersaturation and Media Composition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00927
Abstract: Understanding the supersaturation and precipitation behavior of poorly water-soluble compounds in vivo and the impact on oral absorption is critical to design consistently performing products with optimized bioavailability. Weakly basic compounds are of particular importance… read more here.
Keywords: poorly water; phase; supersaturation; weakly basic ... See more keywords
Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00967
Abstract: While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of… read more here.
Keywords: delivery; nanogels delivery; delivery poorly; poorly water ... See more keywords