Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2018.1462429
Abstract: ABSTRACT The linear pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) can be considered a class property with values that are similar to endogenous IgG. Knowledge of these parameters across species could be used to avoid… read more here.
Keywords: poppk; monoclonal antibodies; human cynomolgus; cynomolgus monkey ... See more keywords
Real-world study of population pharmacokinetic-guided pdVWF/FVIII (1:1) prophylaxis in people with severe von Willebrand disease: The PopPK-WILPROPHY study
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DOI: 10.1182/blood-2025-4856
Abstract: Introduction: Prophylaxis with a von Willebrand factor (VWF)-containing concentrate is recommended for individuals with von Willebrand disease (VWD) with severe and recurrent bleeds. Tailoring of prophylaxis to individual patients has been shown to increase the… read more here.
Keywords: fviii prophylaxis; prophylaxis; study; poppk ... See more keywords