Population Pharmacokinetic Modelling and Limited Sampling Strategies for Therapeutic Drug Monitoring of Pyrazinamide in Patients with Tuberculosis
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DOI: 10.1128/aac.00003-22
Abstract: Pyrazinamide is one of the first-line antituberculosis drugs. The efficacy of pyrazinamide is associated with the ratio of 24-h area under the concentration–time curve (AUC24) to MIC. ABSTRACT Pyrazinamide is one of the first-line antituberculosis… read more here.
Keywords: poppk model; therapeutic drug; limited sampling; population pharmacokinetic ... See more keywords
Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1016399
Abstract: Objective: The aim of this study was to identify the important factors affecting cyclosporine (CsA) blood concentration and estimate CsA concentration using seven different machine learning (ML) algorithms. We also assessed the predictability of established… read more here.
Keywords: poppk model; machine learning; f20 f30; cyclosporine ... See more keywords
Prospective Validation and Refinement of a Population Pharmacokinetic Model of Fludarabine in Children and Young Adults Undergoing Hematopoietic Cell Transplantation
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DOI: 10.3390/pharmaceutics14112462
Abstract: Fludarabine is a nucleoside analog with antileukemic and immunosuppressive activity commonly used in allogeneic hematopoietic cell transplantation (HCT). Several fludarabine population pharmacokinetic (popPK) and pharmacodynamic models have been published enabling the movement towards precision dosing… read more here.
Keywords: fludarabine; poppk model; cell transplantation; population pharmacokinetic ... See more keywords