Use of normalized prediction distribution errors for assessing population physiologically-based pharmacokinetic model adequacy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-020-09684-2
Abstract: Currently employed methods for qualifying population physiologically-based pharmacokinetic (Pop-PBPK) model predictions of continuous outcomes (e.g., concentration–time data) fail to account for within-subject correlations and the presence of residual error. In this study, we propose a… read more here.
Keywords: population physiologically; model; pop pbpk; pbpk ... See more keywords
Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling
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DOI: 10.3390/antib13030054
Abstract: The objective of this work was to develop a population physiologically based pharmacokinetic (popPBPK) model to characterize the variability in the clinical PK of monoclonal antibodies (mAbs) following intravenous (IV) and subcutaneous (SC) administration. An… read more here.
Keywords: variability; physiologically based; model; inter antibody ... See more keywords