Graphtyper enables population-scale genotyping using pangenome graphs
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3964
Abstract: A fundamental requirement for genetic studies is an accurate determination of sequence variation. While human genome sequence diversity is increasingly well characterized, there is a need for efficient ways to use this knowledge in sequence… read more here.
Keywords: sequence; graphtyper; population scale; variation ... See more keywords
NanoPack2: population-scale evaluation of long-read sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad311
Abstract: Summary Increases in the cohort size in long-read sequencing projects necessitate more efficient software for quality assessment and processing of sequencing data from Oxford Nanopore Technologies and Pacific Biosciences. Here we describe novel tools for… read more here.
Keywords: population scale; sequencing data; nanopack2 population; scale evaluation ... See more keywords
A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2020.0230
Abstract: Multi-scale epidemic forecasting models have been used to inform population-scale predictions with within-host models and/or infection data collected in longitudinal cohort studies. However, most multi-scale models are complex and require significant modelling expertise to run.… read more here.
Keywords: framework; multi scale; patient level; population ... See more keywords
How the epidemiology of disease-resistant and disease-tolerant varieties affects grower behaviour
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2022.0517
Abstract: Population-scale effects of resistant or tolerant crop varieties have received little consideration from epidemiologists. When growers deploy tolerant crop, population-scale disease pressures are often unaffected. This only benefits growers using tolerant varieties, selfishly decreasing yields… read more here.
Keywords: crop; tolerant crop; population scale; disease ... See more keywords
Evaluating the cost of managing patients with cellulitis in Wales, UK: A 20-year population-scale study.
Sign Up to like & getrecommendations! Published in 2023 at "International wound journal"
DOI: 10.1111/iwj.14088
Abstract: This study aimed to estimate costs associated with managing patients with cellulitis from the UK National Health Service (NHS) perspective. The analysis was undertaken through the Secure Anonymised Information Linkage Databank, which brings together population-scale,… read more here.
Keywords: patients cellulitis; population scale; cellulitis; managing patients ... See more keywords
Priority effects within coinfected hosts can drive unexpected population‐scale patterns of parasite prevalence
Sign Up to like & getrecommendations! Published in 2018 at "Oikos"
DOI: 10.1111/oik.05937
Abstract: Organisms are frequently coinfected by multiple parasite strains and species, and interactions between parasites within hosts are known to influence parasite prevalence and diversity, as well as epidemic timing. Importantly, interactions between coinfecting parasites can… read more here.
Keywords: priority effects; priority; host; parasite prevalence ... See more keywords
Spatial chromatin architecture alteration by structural variations in human genomes at the population scale
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology"
DOI: 10.1186/s13059-019-1728-x
Abstract: BackgroundThe number of reported examples of chromatin architecture alterations involved in the regulation of gene transcription and in disease is increasing. However, no genome-wide testing has been performed to assess the abundance of these events… read more here.
Keywords: structural variations; spatial chromatin; chromatin; gene transcription ... See more keywords
Evolution of HIV-1 within untreated individuals and at the population scale in Uganda
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007167
Abstract: HIV-1 undergoes multiple rounds of error-prone replication between transmission events, resulting in diverse viral populations within and among individuals. In addition, the virus experiences different selective pressures at multiple levels: during the course of infection,… read more here.
Keywords: untreated individuals; evolution hiv; evolution; population scale ... See more keywords
Population-Scale Polymorphic Short Tandem Repeat Provides an Alternative Strategy for Allele Mining in Cotton
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.916830
Abstract: Short tandem repeats (STRs), which vary in size due to featuring variable numbers of repeat units, are present throughout most eukaryotic genomes. To date, few population-scale studies identifying STRs have been reported for crops. Here,… read more here.
Keywords: alternative strategy; population scale; allele mining; strategy ... See more keywords
Identification of Policies Based on Assessment-Optimization Model to Confront Vulnerable Resources System with Large Population Scale in a Big City
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph182413097
Abstract: The conflict between excessive population development and vulnerable resource (including water, food, and energy resources) capacity influenced by multiple uncertainties can increase the difficulty of decision making in a big city with large population scale.… read more here.
Keywords: large population; population scale; model; population ... See more keywords