Population Shift Mechanism for Partial Agonism of AMPA Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.11.3122
Abstract: α-amino-3-hydroxy-5-methyl-4-isoaxazolepropionic acid (AMPA) ionotropic glutamate receptors mediate fast excitatory neurotransmission in the central nervous system, and their dysfunction is associated with neurological diseases. Glutamate binding to ligand-binding domains (LBDs) of AMPA receptors induces channel opening… read more here.
Keywords: ampa; population shift; agonism ampa; ampa receptor ... See more keywords
Sodium-induced population shift drives activation of thrombin
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DOI: 10.1038/s41598-020-57822-0
Abstract: The equilibrium between active E and inactive E* forms of thrombin is assumed to be governed by the allosteric binding of a Na + ion. Here we use molecular dynamics simulations and Markov state models… read more here.
Keywords: shift; induced population; population shift; shift drives ... See more keywords