Evaluation of population stratification adjustment using genome‐wide or exonic variants
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22332
Abstract: Population stratification may cause an inflated type‐I error and spurious association when assessing the association between genetic variations with an outcome. Many genetic association studies are now using exonic variants, which captures only 1% of… read more here.
Keywords: genome wide; association; exonic variants; population stratification ... See more keywords
Control for population stratification in genetic association studies based on GWAS summary statistics
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DOI: 10.1002/gepi.22493
Abstract: Over the past years, genome‐wide association studies (GWAS) have generated a wealth of new information. Summary data from many GWAS are now publicly available, promoting the development of many statistical methods for association studies based… read more here.
Keywords: population; control population; population stratification; association studies ... See more keywords
The influence of population stratification on genetic markers associated with type 1 diabetes
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DOI: 10.1038/srep43513
Abstract: Ethnic admixtures may interfere with the definition of type 1 diabetes (T1D) risk determinants. The role of HLA, PTPN22, INS-VNTR, and CTLA4 in T1D predisposition was analyzed in Brazilian T1D patients (n = 915), with 81.7% self-reporting… read more here.
Keywords: t1d; drb1 dqb1; type diabetes; population stratification ... See more keywords
Leveraging family data to design Mendelian Randomization that is provably robust to population stratification.
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DOI: 10.1101/gr.277664.123
Abstract: Mendelian Randomization (MR) has emerged as a powerful approach to leverage genetic instruments to infer causality between pairs of traits in observational studies. However, the results of such studies are susceptible to biases due to… read more here.
Keywords: provably robust; mendelian randomization; family data; population ... See more keywords
A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design
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DOI: 10.3389/fgene.2019.00398
Abstract: Extreme phenotype sampling (EPS) is a popular study design used to reduce genotyping or sequencing costs. Assuming continuous phenotype data are available on a large cohort, EPS involves genotyping or sequencing only those individuals with… read more here.
Keywords: phenotype; phenotype sampling; extreme phenotype; population stratification ... See more keywords