Assessing population substructure in the Lebanese population: A population study using data on 23 autosomal short tandem repeats
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2118
Abstract: Understanding the genetic substructure of a population is essential for proper forensic genetic analysis. The Lebanese population has a high rate of endogamous and consanguineous marriages and is segregated based on religious belongings. However, no… read more here.
Keywords: assessing population; lebanese population; population substructure; substructure ... See more keywords
Estimating SNP heritability in presence of population substructure in biobank-scale datasets.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac015
Abstract: SNP heritability of a trait is measured as the proportion of total variance explained by the additive effects of genome-wide single nucleotide polymorphisms (SNPs). Linear mixed models are routinely used to estimate SNP heritability for… read more here.
Keywords: presence; heritability; population substructure; snp heritability ... See more keywords
A pseudolikelihood approach for assessing genetic association in case–control studies with unmeasured population structure
Sign Up to like & getrecommendations! Published in 2020 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280220921212
Abstract: The case–control study design is one of the main tools for detecting associations between genetic markers and diseases. It is well known that population substructure can lead to spurious association between disease status and a… read more here.
Keywords: association; case control; population substructure; population ... See more keywords