Apoptotic mitochondrial poration by a growing list of pore‐forming BCL‐2 family proteins
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DOI: 10.1002/bies.202200221
Abstract: The pore‐forming BCL‐2 family proteins are effectors of mitochondrial poration in apoptosis initiation. Two atypical effectors—BOK and truncated BID (tBID)—join the canonical effectors BAK and BAX. Gene knockout revealed developmental phenotypes in the absence the… read more here.
Keywords: bcl family; pore forming; mitochondrial poration; forming bcl ... See more keywords
Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
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DOI: 10.1038/s41467-018-03651-9
Abstract: Peptide mediated gain-of-toxic function is central to pathology in Alzheimer’s, Parkinson’s and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and… read more here.
Keywords: gain; iapp; poration; toxic gain ... See more keywords
Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms
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DOI: 10.1038/s41598-018-33289-y
Abstract: The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candidates in this… read more here.
Keywords: antimicrobial mechanisms; defense peptides; poration; host defense ... See more keywords
Acoustofluidic cell poration
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DOI: 10.1126/science.368.6492.727-a
Abstract: Gene Delivery Poration methods for introducing genes into cells must achieve sufficient throughput to deliver clinically useful numbers of transfected cells. Belling et al. have enhanced the mechanical poration of cells in microcapillaries by mounting… read more here.
Keywords: poration; cell; cell poration; acoustofluidic cell ... See more keywords