Discovery and Identification of a Novel PORCN Inhibitor via Structure-Based Virtual Screening.
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DOI: 10.1021/acschembio.5c00155
Abstract: Dysregulated activation of the Wnt pathway is closely associated with oncogenesis and the progression of various cancers. Palmitoylation catalyzed by porcupine (PORCN) is essential for the secretion of Wnts and the activation of the Wnt… read more here.
Keywords: based virtual; structure based; virtual screening; porcn inhibitor ... See more keywords
Porcn is essential for growth and invagination of the mammalian optic cup
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.1101/2022.09.01.506058
Abstract: Microphthalmia, anophthalmia, and coloboma (MAC) are congenital ocular malformations causing 25% of childhood blindness. The X-linked disorder Focal Dermal Hypoplasia is frequently associated with MAC and results from mutations in Porcn, a membrane bound O-acyl… read more here.
Keywords: growth; optic cup; porcn essential; eye ... See more keywords