Porcupine's dilemma in kidney fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.07.020
Abstract: Aberrant activation of Wnt/β-catenin signaling, an activity that is critically modulated by porcupine, a membrane-bound O-acyltransferase, is profibrotic. Previously, the Crowley laboratory demonstrated that oral administration of porcupine inhibitor attenuated experimental mouse kidney fibrosis. Now… read more here.
Keywords: porcupine; fibrosis; porcupine dilemma; kidney fibrosis ... See more keywords
Porcupine Inhibitors: Novel and Emerging Anti-cancer Therapeutics Targeting the Wnt Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105532
Abstract: Porcupine is a constituent of the 19 membered Wnt family with diverse biological features such as cell differentiation, cell proliferation, cell migration, apoptosis, etc. Porcupine is a membrane-bound o-acyltransferase family protein that modulates Wnt protein… read more here.
Keywords: porcupine; porcupine inhibitors; inhibitors novel; emerging anti ... See more keywords
Insulin activates hepatic Wnt/β-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61869-4
Abstract: The Wnt/β-catenin pathway plays a pivotal role in liver structural and metabolic homeostasis. Wnt activity is tightly regulated by the acyltransferase Porcupine through the addition of palmitoleate. Interestingly palmitoleate can be endogenously produced by the… read more here.
Keywords: porcupine; wnt; pathway; activity ... See more keywords
Porcupine-dependent wnt activity within the uterine epithelium is essential for fertility
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1093/biolre/iox119
Abstract: Abstract The secretion of mammalian Wnt ligands within the cell is dependent on the activity of Porcupine, a gene located on the X-chromosome that encodes for a membrane-bound O-acyl transferase. Here, we report that postnatal… read more here.
Keywords: porcupine; wnt; porcupine dependent; epithelium ... See more keywords
Abstract 3764: Porcupine inhibitor RXC004 enhances immune response in pre-clinical models of cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3764
Abstract: Background: RXC004, a potent and selective porcupine (PORCN) inhibitor, is being investigated in a safety and tolerability study in cancer patients with solid tumours (CT 2017-000720-98). In addition to the tumour targeting role of RXC004… read more here.
Keywords: porcupine; inhibitor; rxc004; pre clinical ... See more keywords
Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-17-0436
Abstract: Six members of the Wnt family are expressed in the female reproductive tract. Their collective function ensures proper development of the uterus, preparing it for pregnancy during adulthood. Here, we take advantage of the fact… read more here.
Keywords: porcupine; regulation porcupine; mosaic females; function ... See more keywords
The morphology of the penis in porcupine (Hystrix cristata)
Sign Up to like & getrecommendations! Published in 2018 at "Veterinarni Medicina"
DOI: 10.17221/5520-vetmed
Abstract: In this study, histological and macroanatomical structures of porcupine penis were examined on 3 adult male porcupines. The non-erectile position of porcupine penis was directed to caudal. There was an obvious collum penis. Glans penis… read more here.
Keywords: porcupine; morphology penis; penis; porcupine penis ... See more keywords
Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biomaterialia"
DOI: 10.2139/ssrn.4272099
Abstract: Diabetes chronic wound is a severe and frequently occurring medical issue in patients with diabetes that often leads to more serious complications. Microneedles (MNs) can be used for wound healing as they can effectively pierce… read more here.
Keywords: wound; wound healing; diabetic wound; back patching ... See more keywords