Porcupine's dilemma in kidney fibrosis.
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DOI: 10.1016/j.kint.2019.07.020
Abstract: Aberrant activation of Wnt/β-catenin signaling, an activity that is critically modulated by porcupine, a membrane-bound O-acyltransferase, is profibrotic. Previously, the Crowley laboratory demonstrated that oral administration of porcupine inhibitor attenuated experimental mouse kidney fibrosis. Now… read more here.
Keywords: porcupine; fibrosis; porcupine dilemma; kidney fibrosis ... See more keywords