Spatial characterization of heterogeneous nanopore surfaces from XCT scans of Niobrara shale
Sign Up to like & getrecommendations! Published in 2019 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2019.03.081
Abstract: Abstract The multiphase fluid flow through natural and geo-architected nanopore structures is fundamentally controlled by the geometry of such nanopore structures, pore wettability and interfacial tension. Furthermore, multiphase fluid flow through the nanopore structures is… read more here.
Keywords: channel surface; nanopore surfaces; nanopore structures; pore channel ... See more keywords
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24735-z
Abstract: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the… read more here.
Keywords: protein; two pore; naadp receptor; receptor ... See more keywords
The human two-pore channel 1 is modulated by cytosolic and luminal calcium
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43900
Abstract: Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently emerging roles in organellar signalling and involvement in severe human diseases. Here, we investigated the functional properties of human TPC1 expressed in TPC-free vacuoles from… read more here.
Keywords: pore channel; two pore; human two; ca2 ... See more keywords
Two‐pore channel protein TPC1 is a determining factor for the adaptation of proximal tubular phosphate handling
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13914
Abstract: Two‐pore channels (TPCs) constitute a small family of cation channels expressed in endo‐lysosomal compartments. TPCs have been characterized as critical elements controlling Ca2+‐mediated vesicular membrane fusion and thereby regulating endo‐lysosomal vesicle trafficking. Exo‐ and endocytotic… read more here.
Keywords: channel protein; tpc1 determining; two pore; protein tpc1 ... See more keywords
Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092391
Abstract: Melanoma is one of the most aggressive and treatment-resistant human cancers. The two-pore channel 2 (TPC2) is located on late endosomes, lysosomes and melanosomes. Here, we characterized how TPC2 knockout (KO) affected human melanoma cells… read more here.
Keywords: channel tpc2; melanoma cells; two pore; expression ... See more keywords