Two-pore channels as master regulators of membrane trafficking and endocytic well-being
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2020.08.002
Abstract: Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to information… read more here.
Keywords: regulators membrane; pore channels; channels master; master regulators ... See more keywords
On the molecular nature of large-pore channels.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166994
Abstract: Membrane transport is a fundamental means to control basic cellular processes such as apoptosis, inflammation, and neurodegeneration and is mediated by a number of transporters, pumps, and channels. Accumulating evidence over the last half century… read more here.
Keywords: nature large; pore channels; large pore; biology ... See more keywords
Perpendicular Alignment of Covalent Organic Framework (COF) Pore Channels by Solvent Vapor Annealing.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03198
Abstract: Covalent organic frameworks (COFs) have showcased great potential in diverse applications such as separation and catalysis, where mass transfer confined in their pore channels plays a significant role. However, anisotropic orientation usually occurs in polycrystalline… read more here.
Keywords: solvent vapor; pore channels; cof pore; perpendicular alignment ... See more keywords
Spatially confined growth of carbon nanotubes in the pore channels of microporous ceramic supports with improved filtration efficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr03121c
Abstract: Carbon nanotubes (CNTs) with high degrees of uniformity, orientation and controlled dimensions on porous supports are highly desirable for various applications such as separation of O/W emulsions and air purification. In this work, CNTs were… read more here.
Keywords: filtration efficiency; carbon nanotubes; growth; pore channels ... See more keywords
Two-pore channels: going with the flows
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220229
Abstract: In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of… read more here.
Keywords: going flows; channels going; two pore; pore channels ... See more keywords
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209569120
Abstract: Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP2) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC… read more here.
Keywords: pore channels; voltage; domain; two pore ... See more keywords
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2016.1213929
Abstract: ABSTRACT Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates,… read more here.
Keywords: ion channels; pore channels; gated ion; two pore ... See more keywords
Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.51423
Abstract: Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is… read more here.
Keywords: pore channels; voltage; two pore; agonist specific ... See more keywords