Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202415585
Abstract: Triple‐negative breast cancer (TNBC), a highly aggressive subtype, currently lacks potent targeted therapies. ARID1B, a key SWI/SNF chromatin remodeling complex subunit, is linked to high‐grade malignancies and poor prognosis, making it a potential biomarker and… read more here.
Keywords: nuclear pore; arid1b; pore complex; therapeutic strategy ... See more keywords
Unraveling docking and initiation of mRNA export through the nuclear pore complex
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200027
Abstract: The nuclear export of mRNA through the nuclear pore complex (NPC) is a process required for the healthy functioning of human cells, making it a critical area of research. However, the geometries of mRNA and… read more here.
Keywords: nuclear pore; pore complex; nuclear basket; microscopy ... See more keywords
Nuclear Pore Complex Assembly Using Xenopus Egg Extract.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2337-4_3
Abstract: Xenopus egg extract is a powerful tool for the in vitro investigation of complex cellular mechanisms. Here we describe how to obtain and employ interphase Xenopus egg extract to study nuclear pore complex assembly and… read more here.
Keywords: xenopus egg; nuclear pore; egg extract; pore complex ... See more keywords
Polymer translocation through a hairy channel mimicking the inner plug of a nuclear pore complex
Sign Up to like & getrecommendations! Published in 2019 at "European Biophysics Journal"
DOI: 10.1007/s00249-019-01356-5
Abstract: A microscopic transport model of a polymer translocating through a nuclear pore complex (NPC) is presented based on self-consistent field theory (SCFT), with the NPC and its nucleoporins mimicked by a hairy channel. Multiple cell… read more here.
Keywords: polymer; pore complex; effect; translocation ... See more keywords
Sol-gel transition in solutions of FG-Nups of the nuclear pore complex
Sign Up to like & getrecommendations! Published in 2018 at "Extreme Mechanics Letters"
DOI: 10.1016/j.eml.2018.04.006
Abstract: The nuclear pore complex (NPC) is a giant molecular gate that regulates the transport of molecules and macromolecules across the nuclear envelop in a selective and directional manner. Using a coarse-grained one-bead-per-amino-acid model and percolation… read more here.
Keywords: solutions nups; pore complex; sol gel; nuclear pore ... See more keywords
Integrative Structure and Functional Anatomy of a Nuclear Pore Complex
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature26003
Abstract: Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we… read more here.
Keywords: pore complex; anatomy; integrative structure; nuclear pore ... See more keywords
Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis
Sign Up to like & getrecommendations! Published in 2020 at "Cell Research"
DOI: 10.1038/s41422-020-0319-4
Abstract: The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of… read more here.
Keywords: microscopy; pore complex; cytoplasmic ring; nuclear pore ... See more keywords
DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03313-w
Abstract: The nuclear pore complex (NPC) is the gatekeeper for nuclear transport in eukaryotic cells. A key component of the NPC is the central shaft lined with intrinsically disordered proteins (IDPs) known as FG-Nups, which control… read more here.
Keywords: dna origami; pore complex; proteins nuclear; nuclear pore ... See more keywords
Mapping paths through the nuclear pore complex
Sign Up to like & getrecommendations! Published in 2022 at "Nature Cell Biology"
DOI: 10.1038/s41556-021-00823-6
Abstract: Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time… read more here.
Keywords: nuclear pore; pore; pore complex; paths nuclear ... See more keywords
Molecular architecture of coronavirus double-membrane vesicle pore complex
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07817-y
Abstract: Coronaviruses remodel the intracellular host membranes during replication, forming double-membrane vesicles (DMVs) to accommodate viral RNA synthesis and modifications1,2. SARS-CoV-2 non-structural protein 3 (nsp3) and nsp4 are the minimal viral components required to induce DMV… read more here.
Keywords: molecular architecture; pore complex; double membrane; nsp3 nsp4 ... See more keywords
In vivo analysis of protein crowding within the nuclear pore complex in interphase and mitosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05959-w
Abstract: The central channel of the nuclear pore complex (NPC) is occupied by non-structured polypeptides with a high content of Phe-Gly (FG) motifs. This protein-rich environment functions as an entropic barrier that prevents the passage of… read more here.
Keywords: protein; pore complex; rich domains; protein rich ... See more keywords