Portraying the selectivity of GSK-3 inhibitors towards CDK-2 by 3D similarity and molecular docking
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DOI: 10.1007/s11224-018-1224-z
Abstract: The striking structural resemblance between adenosine triphosphate (ATP) binding sites of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinase-2 (CDK-2) raises numerous off-target selectivity problems in lead-identification processes that may jeopardize their progress into safe and… read more here.
Keywords: similarity; portraying selectivity; molecular docking; selectivity ... See more keywords