In vitro activity of posaconazole and comparators versus opportunistic filamentous fungal pathogens globally collected during 8 years.
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2021.115473
Abstract: The epidemiology of invasive filamentous fungal diseases requires monitoring due to changes in susceptibility patterns of new and established antifungal agents that may affect clinical practices. We evaluated the activity of posaconazole against 2,157 invasive… read more here.
Keywords: fumigatus; spp; activity posaconazole; posaconazole ... See more keywords
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.056
Abstract: Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful… read more here.
Keywords: hedgehog signaling; posaconazole based; based analogues; development posaconazole ... See more keywords
Disposition of posaconazole after single oral administration in large falcons (Falco spp): Effect of meal and dosage and a non-compartmental model to predict effective dosage.
Sign Up to like & getrecommendations! Published in 2021 at "Medical mycology"
DOI: 10.1093/mmy/myab019
Abstract: Posaconazole has been used anecdotally to treat aspergillosis in falcons resistant to voriconazole. In human medicine, it is used prophylactically in immunosuppressed human subjects with invasive pulmonary aspergillosis. So far, no studies have been performed… read more here.
Keywords: medicine; administration; meal; posaconazole ... See more keywords
Antifungal prophylactic effectiveness and intrapulmonary concentrations of voriconazole versus posaconazole in lung transplant recipients
Sign Up to like & getrecommendations! Published in 2022 at "Medical Mycology"
DOI: 10.1093/mmy/myac041
Abstract: Abstract Invasive fungal diseases (IFDs) are one of the leading causes of death in lung transplant recipients. This study aimed to compare the antifungal prophylactic effectiveness, intrapulmonary and plasma levels of voriconazole with posaconazole in… read more here.
Keywords: lung transplant; prophylactic effectiveness; posaconazole; transplant recipients ... See more keywords
Posaconazole plasma concentrations in pediatric patients receiving antifungal prophylaxis during neutropenia
Sign Up to like & getrecommendations! Published in 2017 at "Medical Mycology"
DOI: 10.1093/mmy/myw091
Abstract: Abstract Invasive fungal infections are one of the major complications in pediatric patients during prolonged neutropenia after chemotherapy. Evaluation of the efficacy and safety of the triazole posaconazole in these patients is missing. This multicenter… read more here.
Keywords: concentrations pediatric; posaconazole plasma; plasma concentrations; posaconazole ... See more keywords
Posaconazole therapy in children with cystic fibrosis and Aspergillus-related lung disease.
Sign Up to like & getrecommendations! Published in 2019 at "Medical mycology"
DOI: 10.1093/mmy/myz015
Abstract: There is emerging evidence for the role of posaconazole in the management of Aspergillus-related cystic fibrosis (CF) lung disease. The tolerability and efficacy of posaconazole in paediatric CF is not well established. We report a… read more here.
Keywords: cystic fibrosis; posaconazole therapy; lung disease; posaconazole ... See more keywords
Treatment of Posaconazole-Induced Peripheral Neuropathy With Methylprednisolone and Magnesium Infusions: A Case Report.
Sign Up to like & getrecommendations! Published in 2019 at "Open forum infectious diseases"
DOI: 10.1093/ofid/ofz031
Abstract: The tolerability of long-term posaconazole use remains poorly defined. We present a patient who developed peripheral neuropathy following long-term exposure to the tablet formulation of posaconazole, which was treated with methylprednisolone and magnesium infusions. The… read more here.
Keywords: magnesium infusions; posaconazole; peripheral neuropathy; methylprednisolone magnesium ... See more keywords
Novel approaches to antifungal therapy
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14616
Abstract: Invasive fungal infections remain a major cause of morbidity and mortality in the solid organ transplant population. NonAspergillus infections are of particular concern due to the reduced antifungal susceptibility of many of these fungi (Scedopsorium,… read more here.
Keywords: antifungal therapy; treatment; drug; toxicity ... See more keywords
Elevated posaconazole trough concentrations are not associated with increased risk for posaconazole toxicity in lung transplant recipients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14826
Abstract: Posaconazole is used for prophylaxis and treatment of invasive fungal infections in lung transplant recipients (LTR). Previous studies have not described the relationship between elevated posaconazole trough concentrations and adverse drug reactions in this population. read more here.
Keywords: transplant recipients; lung transplant; elevated posaconazole; trough concentrations ... See more keywords
Progress of triazole antifungal agent posaconazole in individualized therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13821
Abstract: Posaconazole is the second‐generation triazole antifungal agent with widespread clinical application. Posaconazole exposure is influenced by various factors such as drug interactions, disease state and diet, resulting in a high interindividual variability in many patients… read more here.
Keywords: triazole antifungal; individualized therapy; antifungal agent; posaconazole ... See more keywords
Oral Posaconazole or Intravenous-Oral Itraconazole in Preventing Invasive Fungal Diseases for Patients with Acute Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141508
Abstract: Background and Objectives: Invasive fungal diseases (IFDs) are major and lethal infectious complications for patients with neutropenia after chemotherapy for acute leukemia (AL). We aimed to compare the use of oral posaconazole vs. itraconazole in… read more here.
Keywords: intravenous oral; oral posaconazole; oral itraconazole; group ... See more keywords