Philadelphia chromosome‐positive acute lymphoblastic leukemia at first relapse in the era of tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25648
Abstract: Despite the advances in the management of Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) with the introduction of tyrosine kinase inhibitors (TKIs), relapses remain challenging. We reviewed clinical data from adult patients with Ph + ALL who… read more here.
Keywords: first relapse; positive acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Prognostic factors for progression in patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia in complete molecular response within 3 months of therapy with tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer"
DOI: 10.1002/cncr.33529
Abstract: The achievement of a 3‐month complete molecular response (CMR) is a major prognostic factor for survival in patients with Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukemia (ALL). However, 25% of patients relapse during therapy with tyrosine… read more here.
Keywords: molecular response; positive acute; patients philadelphia; complete molecular ... See more keywords
Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-019-0603-z
Abstract: With the introduction of tyrosine kinase inhibitors (TKIs) in the management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), the prognosis of patients has improved dramatically. Currently, the standard of care in the frontline setting… read more here.
Keywords: positive acute; treatment; lymphoblastic leukemia; chromosome positive ... See more keywords
Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-79065-9
Abstract: The immune system of sturgeons, one of the most ancient and economically valuable fish worldwide, is poorly understood. The lack of molecular tools and data about infection biomarkers hinders the possibility to monitor sturgeon health… read more here.
Keywords: acute phase; protein; saa; positive acute ... See more keywords
Novel third-generation tyrosine kinase inhibitor for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a case study
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001455
Abstract: Although Philadelphia chromosome-positive acute leukemia (Ph+-ALL) has been revolutionized with tyrosine kinase inhibitors (TKIs), resistance and mutation are universal events during treatment with first-generation and second-generation TKIs. The present third-generation TKI has a dose-dependent, increased… read more here.
Keywords: newly diagnosed; generation; chromosome positive; philadelphia chromosome ... See more keywords
IKZF1plus alterations are not associated with outcomes in Philadelphia-positive acute lymphoblastic leukemia patients enrolled in the FBMTG ALL/MRD2008 trial.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of haematology"
DOI: 10.1111/ejh.13972
Abstract: The prognostic significance of IKZF1plus in adult Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) patients had remained to be clarified. read more here.
Keywords: leukemia patients; lymphoblastic leukemia; philadelphia positive; acute lymphoblastic ... See more keywords
Droplet digital polymerase chain reaction improves the detection of BCR-ABL1 kinase domain mutation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14069
Abstract: INTRODUCTION Sanger sequencing (SS) is the most frequently used method for detecting ABL1 kinase domain (KD) mutations in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). However, it cannot detect low levels of mutation.… read more here.
Keywords: kinase domain; chromosome positive; abl1 kinase; philadelphia chromosome ... See more keywords
Patient preferences for frontline therapies for Philadelphia chromosome-positive acute lymphoblastic leukemia: a discrete choice experiment.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0082
Abstract: Aim: We examined the preferences of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) for benefits and risks of tyrosine kinase inhibitors combined with chemotherapy for first-line treatment. Methods: In a discrete choice experiment, 201… read more here.
Keywords: chromosome positive; philadelphia chromosome; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia
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DOI: 10.3324/haematol.2018.196055
Abstract: To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116… read more here.
Keywords: positive acute; lymphoblastic leukemia; acute lymphoblastic; chromosome positive ... See more keywords
Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in Adults
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DOI: 10.3390/cancers14071805
Abstract: Simple Summary Outcome of patients with Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) dramatically improved during the past 20 years with the advent of tyrosine kinase inhibitors and monoclonal antibodies. Their great efficacy in young… read more here.
Keywords: acute lymphoblastic; chromosome positive; philadelphia chromosome; lymphoblastic leukemia ... See more keywords
Gene mutation profile and risk stratification in AML1-ETO-positive acute myeloid leukemia based on next-generation sequencing
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DOI: 10.3892/or.2019.7375
Abstract: Gene mutations play an important role in the development and progression of AML1-ETO-positive acute myeloid leukemia (AE-AML). Nevertheless, the gene mutation profile in this subtype of leukemia remains unclear. In addition, the clinical and prognostic… read more here.
Keywords: aml1 eto; eto positive; positive acute; gene ... See more keywords