Relatively favorable outcome after allogeneic stem cell transplantation for BCR‐ABL1‐positive AML: A survey from the acute leukemia working party of the European Society for blood and marrow transplantation (EBMT)
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DOI: 10.1002/ajh.24928
Abstract: The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR‐ABL1‐positive acute myeloid leukemia (AML). Fifty‐seven patients (median age, 48 years, range: 19‐67) with BCR‐ABL1… read more here.
Keywords: abl1 positive; positive aml; transplantation; sct ... See more keywords
Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress.
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DOI: 10.1016/j.canlet.2019.03.046
Abstract: FLT3-ITD and FLT3-TKD are the most frequent mutations in acute myeloid leukemia (AML) with the former associated with a poor prognosis. Here we show that inhibition of the deubiquitinase USP9X by its inhibitor WP1130 or… read more here.
Keywords: flt3 itd; itd; positive aml; itd positive ... See more keywords
Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
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DOI: 10.1038/s41375-018-0291-x
Abstract: Over the past decade, several inhibitors of key metabolic dependencies have been shown to be active in AML (Acute Myeloid Leukemia), suggesting that targeting cellular metabolism is a promising therapeutic strategy for this disease. Specific… read more here.
Keywords: creatine; evi1 positive; inhibition; positive aml ... See more keywords
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML
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DOI: 10.1038/s41375-021-01462-4
Abstract: FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possibly improve therapy response… read more here.
Keywords: flt3 itd; itd; positive aml; itd positive ... See more keywords
Adding Midostaurin to Intensive Chemotherapy in FLT3-Positive AML Patients. Results from a Multicenter Historical-Controlled Study
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DOI: 10.1182/blood-2018-99-114154
Abstract: Introduction: The phase III RATIFY study (Stone et al, NEJM 2017) demonstrated that the addition of the FLT3 inhibitor midostaurin to intensive induction and consolidation courses improves outcome in younger FLT3-positive AML patients. The toxicity… read more here.
Keywords: control; midostaurin control; group; flt3 positive ... See more keywords