Rapid, label‐free antibiotic susceptibility determined directly from positive blood culture
Sign Up to like & getrecommendations! Published in 2022 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24560
Abstract: Bacterial bloodstream infections are a significant cause of global morbidity and mortality. Constrained by low bacterial burdens of 1–100 colony‐forming‐units per ml blood (CFU/ml), clinical diagnosis relies on lengthy culture amplification and isolation steps prior… read more here.
Keywords: culture; positive blood; blood culture; antibiotic susceptibility ... See more keywords
Studies that report unexpected positive blood cultures for Lyme borrelia - are they valid?
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.07.009
Abstract: Positive blood cultures for Lyme borrelia have been well documented in untreated patients with early Lyme disease. In this report we review the validity of three studies that reported the recovery of Borrelia burgdorferi sensu… read more here.
Keywords: blood cultures; cultures lyme; disease; blood ... See more keywords
Staphylococcus pettenkoferi-positive Blood cultures in Hospitalized Patients in a Multi-site Tertiary Center.
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2020.115284
Abstract: Staphylococcus pettenkoferi (S.pettenkoferi), originally described in Germany in 2002 by Trülzsch et al, is a coagulase negative staphylococcus whose clinical relevance is yet to be determined. With about 10 case reports in the literature from several… read more here.
Keywords: positive blood; pettenkoferi positive; blood cultures; staphylococcus pettenkoferi ... See more keywords
Direct bacterial identification from positive blood cultures using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Enfermedades infecciosas y microbiologia clinica"
DOI: 10.1016/j.eimc.2017.08.012
Abstract: INTRODUCTION The rapid identification of bacteraemia-causing pathogens could assist clinicians in the timely prescription of targeted therapy, thereby reducing the morbidity and mortality of this infection. In recent years, numerous techniques that rapidly and directly… read more here.
Keywords: mass spectrometry; maldi tof; identification; positive blood ... See more keywords
Impact of early antimicrobial stewardship intervention in patients with positive blood cultures: results from a randomized comparative study: Impact of stewardship on BSI outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106490
Abstract: BACKGROUND Antimicrobial stewardship intervention (ASI) appears necessary to realize the full benefits of rapid diagnostic technologies in clinical practice. This study aimed to compare clinical outcomes between early ASI paired with MALDI-TOF compared to MALDI-TOF… read more here.
Keywords: time; patients positive; stewardship; blood cultures ... See more keywords
Direct antimicrobial susceptibility tests of bacteria and yeasts from positive blood cultures by using serum separator gel tubes and MALDI-TOF MS.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2018.12.011
Abstract: Early and appropriate antimicrobial treatment can effectively reduce the mortality rate caused by bloodstream infections (BSIs) and is critical for favorable patient outcomes. In general, >90% of positive blood cultures will show positive results within… read more here.
Keywords: blood cultures; serum separator; bacteria yeasts; positive blood ... See more keywords
Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Perinatology"
DOI: 10.1038/s41372-018-0141-8
Abstract: Intervention: Infants that met inclusion criteria were observed in the mother–infant unit. An initial blood culture, complete blood count with manual differential (CBC), and high-sensitivity C-reactive protein (hsCRP) were obtained at 0–6 h of life.… read more here.
Keywords: mother infant; infant unit; blood; chorioamnionitis ... See more keywords
Direct, rapid antimicrobial susceptibility test from positive blood cultures based on microscopic imaging analysis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01278-2
Abstract: For the timely treatment of patients with infections in bloodstream and cerebrospinal fluid, a rapid antimicrobial susceptibility test (AST) is urgently needed. Here, we describe a direct and rapid antimicrobial susceptibility testing (dRAST) system, which… read more here.
Keywords: susceptibility; rapid antimicrobial; antimicrobial susceptibility; test ... See more keywords
Evaluation of the MBT STAR-Carba Assay for the Detection of Carbapenemase Production in Enterobacteriaceae and Hafniaceae with a Large Collection of Routine Isolates from Plate Cultures and Patient-Derived Positive Blood Cultures.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0466
Abstract: The spread of carbapenemase-producing Enterobacterales is a major public health concern worldwide, and methods for their prompt and reliable detection are highly demanded for therapeutic and hygiene control purposes. In this study, we evaluate the… read more here.
Keywords: plate cultures; carbapenemase; star carba; carba assay ... See more keywords
Effective implementation of the Accelerate Pheno™ system for positive blood cultures
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky534
Abstract: Abstract Using conventional methods, organism identification (ID) and antibiotic susceptibility testing (AST) results are available ∼1.5–3 days after positive blood culture. New technologies can reduce this time to 8–12 h, allowing therapy to be optimized substantially sooner.… read more here.
Keywords: implementation accelerate; positive blood; ast results; effective implementation ... See more keywords
The EUCAST rapid disc diffusion method for antimicrobial susceptibility testing directly from positive blood culture bottles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz548
Abstract: Abstract Objectives With increasing antimicrobial resistance, rapid antimicrobial susceptibility testing (RAST) becomes important, especially in patients with bloodstream infections. EUCAST decided to develop a standardized rapid method, based on EUCAST disc diffusion, to offer susceptibility… read more here.
Keywords: susceptibility testing; susceptibility; method; antimicrobial susceptibility ... See more keywords