WEE1 inhibition reverses trastuzumab resistance in HER2-positive cancers
Sign Up to like & getrecommendations! Published in 2021 at "Gastric Cancer"
DOI: 10.1007/s10120-021-01176-7
Abstract: To date, many efforts have been made to understand the resistance mechanism of trastuzumab in human epidermal growth factor receptor 2 (HER2)-positive breast and gastric cancer. However, there is still a huge unmet medical need… read more here.
Keywords: positive cancers; trastuzumab resistance; her2 positive; resistance ... See more keywords
A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01237-3
Abstract: Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and biodistribution study of DS-8895a, an anti-EphA2 antibody, in patients with advanced EphA2 positive cancers.… read more here.
Keywords: patients advanced; biodistribution; positive cancers; antibody ... See more keywords
Abstract PR02: Clinical proof of concept for MCLA-128, a bispecific HER2/3 antibody therapy, inNRG1fusion-positive cancers
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DOI: 10.1158/1535-7163.targ-19-pr02
Abstract: Background: NRG1 fusions are oncogenic drivers of various cancers including pancreatic and lung adenocarcinomas. NRG1 fusion proteins bind to HER3, leading to HER2/HER3 heterodimerization, increased downstream signaling, and tumor growth. MCLA-128 is a bispecific antibody… read more here.
Keywords: positive cancers; 128 bispecific; her2; antibody ... See more keywords
Development of a Humanized VHH Based Recombinant Antibody Targeting Claudin 18.2 Positive Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.885424
Abstract: Claudin 18.2 (CLDN18.2), a tight junction (TJ) family protein controlling molecule exchange between cells, is frequently over-expressed in gastric cancer, pancreatic adenocarcinomas and in a fraction of non–small cell lung cancer cases. The tumor properties… read more here.
Keywords: positive cancers; cldn18; humanized vhh; development humanized ... See more keywords
The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers
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DOI: 10.3390/pathogens9050403
Abstract: High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to HPV-related cancers, although the exact nature of the interactions remains to be… read more here.
Keywords: positive cancers; estrogen; related signaling; relationship estrogen ... See more keywords