Structure–activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity
Sign Up to like & getrecommendations! Published in 2017 at "Peptides"
DOI: 10.1016/j.peptides.2017.03.002
Abstract: &NA; Recent years have brought in an increased interest to develop improved polymyxins. The currently used polymyxins, i.e. polymyxin B and colistin (polymyxin E) are pentacationic lipopeptides that possess a cyclic heptapeptide part with three… read more here.
Keywords: part; class; three positive; positive charges ... See more keywords
Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00834
Abstract: Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is… read more here.
Keywords: teixobactin; teixobactin cationic; positive charges; antimicrobial peptide ... See more keywords
MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1280219
Abstract: ABSTRACT During the process of oxidative phosphorylation, protons are pumped into the mitochondrial intermembrane space to establish a mitochondrial membrane potential (MMP). The electrochemical gradient generated allows protons to return to the matrix through the… read more here.
Keywords: mitoq regulates; positive charges; membrane potential; mitochondrial membrane ... See more keywords
Coulomb Planar Periodic Motion of Equal Charges in the Field of Equal Positive Charges Fixed at a Line and Constant Magnetic Field
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DOI: 10.1155/2018/2548074
Abstract: We consider a neutral Coulomb planar system of equal negative charges in a constant magnetic field and a field of equal fixed positive charges and construct a periodic solution of the equation of motion such… read more here.
Keywords: field; coulomb planar; positive charges; magnetic field ... See more keywords
Influence of Cationic meso-Substituted Porphyrins on the Antimicrobial Photodynamic Efficacy and Cell Membrane Interaction in Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20010134
Abstract: Photodynamic inactivation (PDI) is a non-antibiotic option for the treatment of infectious diseases. Although Gram-positive bacteria have been shown to be highly susceptible to PDI, the inactivation of Gram-negative bacteria has been more challenging due… read more here.
Keywords: cell membrane; positive charges; interaction; cell ... See more keywords