TGF‐β1‐PML SUMOylation‐peptidyl‐prolyl cis–trans isomerase NIMA‐interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27357
Abstract: Transforming growth factor‐β (TGF‐β) signaling pathway is involved in fibrosis in most, if not all forms of cardiac diseases. Here, we evaluate a positive feedback signaling the loop of TGF‐β1/promyelocytic leukemia (PML) SUMOylation/Pin1 promoting the… read more here.
Keywords: positive feedback; fibrosis; tgf; pml ... See more keywords
Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23102
Abstract: Sorafenib is the standard first‐line systemic chemotherapeutic drugs for advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is frequently observed in clinical practice. In this study, we first produced three sorafenib resistance (SR) HCC… read more here.
Keywords: positive feedback; hcc; feedback loop; sorafenib ... See more keywords
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05333-w
Abstract: According to psychological theories, cognitive distortions play a pivotal role in the aetiology and recurrence of mood disorders. Although clinical evidence for the coexistence of depression and altered sensitivity to performance feedback is relatively coherent,… read more here.
Keywords: positive feedback; trait; sensitivity negative; feedback ... See more keywords
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02678-6
Abstract: The clinical success of immune checkpoint blockade against diverse human cancers highlights the critical importance of insightful understanding into mechanisms underlying PD-L1 regulation. IFN-γ released by intratumoral lymphocytes regulates PD-L1 expression in tumor cells through… read more here.
Keywords: positive feedback; feedback loop; cancer; irf1 ... See more keywords
The effect of adolescents’ active social networking site use on life satisfaction: The sequential mediating roles of positive feedback and relational certainty
Sign Up to like & getrecommendations! Published in 2018 at "Current Psychology"
DOI: 10.1007/s12144-018-9882-y
Abstract: The present research tested the mediating roles of positive feedback and relational certainty in the relation between active social networking site use and life satisfaction. A survey research method was adopted in which four anonymous… read more here.
Keywords: positive feedback; social networking; site use; networking site ... See more keywords
MiR-135b promotes HCC tumorigenesis through a positive-feedback loop.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.008
Abstract: Hippo pathway plays critical roles in cell proliferation and apoptosis and its dysregulation leads to various types of cancers, including hepatocellular carcinoma (HCC). However, the mechanism maintaining Hippo pathway homeostasis still remains unclear. In this… read more here.
Keywords: positive feedback; mir 135b; hcc; hippo pathway ... See more keywords
Impact of Zygosity on Bimodal Phenotype Distributions.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.010
Abstract: Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when… read more here.
Keywords: positive feedback; gene expression; zygosity; gene ... See more keywords
Positive feedback exists and drives the glucose-mediated repression in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.01.017
Abstract: The expression of the lac operon of E. coli is subject to positive feedback during growth in the presence of gratuitous inducers, but its existence in the presence of lactose remains controversial. The key question… read more here.
Keywords: induction; feedback; presence; repression ... See more keywords
Mitochondrial fission forms a positive feedback loop with cytosolic calcium signaling pathway to promote autophagy in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.05.034
Abstract: Both mitochondrial morphology and the level of cytosolic calcium [Ca2+]c are actively changed and play critical roles in a number of malignancies. However, whether communications existed between these two processes to ingeniously control the malignant… read more here.
Keywords: positive feedback; cytosolic calcium; mitochondrial fission; calcium ... See more keywords
Positive feedback amplification in swarming immune cell populations.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2021.07.009
Abstract: Several immune cell types (neutrophils, eosinophils, T cells, and innate-like lymphocytes) display coordinated migration patterns when a population, formed of individually responding cells, moves through inflamed or infected tissues. "Swarming" refers to the process in… read more here.
Keywords: positive feedback; immune cell; feedback amplification; cell ... See more keywords
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.092
Abstract: SUMMARY Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report… read more here.
Keywords: positive feedback; liver fibrosis; feedback loop; tgf ... See more keywords