Genetic and immune microenvironment characterization of HER2‐positive gastric cancer: Their association with response to trastuzumab‐based treatment
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DOI: 10.1002/cam4.5769
Abstract: We aimed to determine the molecular and immune microenvironment characteristics of HER2‐positive gastric cancer (GC) related to the patient's response to first‐line trastuzumab‐based treatment. read more here.
Keywords: positive gastric; immune microenvironment; trastuzumab based; gastric cancer ... See more keywords
Chk1 activation attenuates sensitivity of lapatinib in HER2‐positive gastric cancer
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DOI: 10.1002/cbin.10922
Abstract: The ATM and Rad3‐related (ATR)/checkpoint kinase 1 (Chk1) pathway plays a pivotal role in DNA damage sensor and modulating homologous recombination. Recently, emerging evidence demonstrated that Chk1 phosphorylation was associated with chemotherapy and radiotherapy resistance.… read more here.
Keywords: chk1; positive gastric; her2 positive; gastric cancer ... See more keywords
Landscape of EBV-positive gastric cancer
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DOI: 10.1007/s10120-021-01215-3
Abstract: Epstein–Barr virus-positive gastric cancer [EBV (+) GC] is associated with EBV infection and is one of the GC subtypes defined by the Cancer Genome Atlas. EBV (+) GC has several distinct genomic or epigenomic features… read more here.
Keywords: positive gastric; gastric cancer; cancer landscape; ebv encoded ... See more keywords
Prognostic Factors in Patients with Advanced HER2-Positive Gastric Cancer Treated with Trastuzumab-Based Chemotherapy: a Cohort Study
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DOI: 10.1007/s12029-022-00815-1
Abstract: Prognostic factors for the survival of patients with advanced HER2-positive gastric cancer treated with trastuzumab-based chemotherapy remain controversial. The aim of this study was to identify the clinical factors that predict prognosis in patients with… read more here.
Keywords: positive gastric; cancer; her2 positive; gastric cancer ... See more keywords
Benchmarks for nodal yield and ratio for node-positive gastric cancer.
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DOI: 10.1016/j.surg.2021.04.026
Abstract: BACKGROUND We aimed to elucidate prognostic markers of node-positive gastric cancers with a focus on examined lymph nodes and lymph node ratio. METHODS Patients treated with curative-intent gastrectomy at The University of Texas MD Anderson… read more here.
Keywords: positive gastric; node positive; ratio; overall survival ... See more keywords
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
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DOI: 10.1038/s41586-021-04161-3
Abstract: Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) amplification or overexpression occurs in approximately 20% of advanced gastric or gastro-oesophageal junction adenocarcinomas1-3. More than a decade ago, combination therapy with the anti-HER2 antibody… read more here.
Keywords: keynote 811; positive gastric; her2; her2 positive ... See more keywords
Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis: Erratum
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DOI: 10.1097/md.0000000000009530
Abstract: [1] In the article, “Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis” , which appeared in Volume 96, Issue 44 of Medicine, the corresponding author’s address should appear as Jian Zhang, Department of General… read more here.
Keywords: medicine; positive gastric; her2 positive; associated her2 ... See more keywords
EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics
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DOI: 10.3889/oamjms.2018.409
Abstract: BACKGROUND: The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein… read more here.
Keywords: gastric carcinomas; ebv; positive gastric; carcinoma ... See more keywords
Circulating Tumor DNA as a Predictive Biomarker for Clinical Outcomes With Margetuximab and Pembrolizumab in Pretreated HER2-Positive Gastric/ Gastroesophageal Adenocarcinoma.
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DOI: 10.46883/2023.25920992
Abstract: PURPOSE To assess the ability of circulating tumor DNA (ctDNA)-based testing to identify patients with HER2 (encoded by ERBB2)-positive gastric/gastroesophageal adenocarcinoma (GEA) who progressed on or after trastuzumab-containing treatments were treated with combination therapy of… read more here.
Keywords: circulating tumor; positive gastric; study entry; her2 ... See more keywords