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Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14300
Abstract: Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers…
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Keywords:
omecamtiv mecarbil;
cardiomyocyte contractile;
mecarbil augments;
augments cardiomyocyte ... See more keywords
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Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.034
Abstract: HighlightsA simple, rapid and efficient pretreatment of AF‐HF001 is reported.A full validated LC–MS/MS method of AF‐HF001 is described for the first time.Successful application to a pharmacokinetics study of AF‐HF001 in mice plasma.First mice pharmacokinetics report…
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Keywords:
application pharmacokinetics;
isonicotinylhydrazide derivative;
positive inotropic;
hf001 ... See more keywords
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Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001235
Abstract: ABSTRACT OR-1855 and OR-1896 are two hemodynamically active metabolites of the inodilator levosimendan, with calcium sensitizing activity, but their mechanism of action is still not fully understood.It has been previously reported that the positive inotropic…
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Keywords:
inotropic effect;
positive inotropic;
forskolin;
active metabolites ... See more keywords
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Published in 2020 at "Experimental physiology"
DOI: 10.1113/ep087964
Abstract: NEW FINDINGS What is the central question of this study? Although ivabradine therapeutic effect on patients with chronic heart failure and chronic stable angina pectoris, is mediated through the reduction in heart rate, the hemodynamic…
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Keywords:
heart;
positive inotropic;
effect;
inotropic effect ... See more keywords
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Published in 2018 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-018-0791-z
Abstract: Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the…
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Keywords:
effect human;
glucagon;
heart;
positive inotropic ... See more keywords