Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14300
Abstract: Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers… read more here.
Keywords: omecamtiv mecarbil; cardiomyocyte contractile; mecarbil augments; augments cardiomyocyte ... See more keywords
Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC–MS/MS and its application to a pharmacokinetics study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.034
Abstract: HighlightsA simple, rapid and efficient pretreatment of AF‐HF001 is reported.A full validated LC–MS/MS method of AF‐HF001 is described for the first time.Successful application to a pharmacokinetics study of AF‐HF001 in mice plasma.First mice pharmacokinetics report… read more here.
Keywords: application pharmacokinetics; isonicotinylhydrazide derivative; positive inotropic; hf001 ... See more keywords
The adenylate cyclase activator forskolin potentiates the positive inotropic effect of the phosphodiesterase inhibitor milrinone but not of the calcium sensitizer levosimendan nor of its hemodynamically active metabolites: an apparent conundrum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001235
Abstract: ABSTRACT OR-1855 and OR-1896 are two hemodynamically active metabolites of the inodilator levosimendan, with calcium sensitizing activity, but their mechanism of action is still not fully understood.It has been previously reported that the positive inotropic… read more here.
Keywords: inotropic effect; positive inotropic; forskolin; active metabolites ... See more keywords
Increased SERCA2a activity underlies the mechanism of positive inotropic effect of ivabradine.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental physiology"
DOI: 10.1113/ep087964
Abstract: NEW FINDINGS What is the central question of this study? Although ivabradine therapeutic effect on patients with chronic heart failure and chronic stable angina pectoris, is mediated through the reduction in heart rate, the hemodynamic… read more here.
Keywords: heart; positive inotropic; effect; inotropic effect ... See more keywords
Does glucagon have a positive inotropic effect in the human heart?
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-018-0791-z
Abstract: Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the… read more here.
Keywords: effect human; glucagon; heart; positive inotropic ... See more keywords