Modulation of in vitro epileptiform activity by optogenetic stimulation of parvalbumin-positive interneurons.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00192.2022
Abstract: GABAA signaling is surprisingly involved in the initiation of epileptiform activity since increased interneuron firing, presumably leading to excessive GABA release, often precedes ictal discharges. Field potential theta (4-12 Hz) oscillations, which are thought to… read more here.
Keywords: parvalbumin positive; epileptiform activity; optogenetic stimulation; stimulation ... See more keywords
Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.886629
Abstract: Parvalbumin-positive neurons are the largest class of GABAergic, inhibitory neurons in the central nervous system. In the cortex, these fast-spiking cells provide feedforward and feedback synaptic inhibition onto a diverse set of cell types, including… read more here.
Keywords: parvalbumin positive; adulthood; development; plasticity ... See more keywords
Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.807090
Abstract: GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function is associated… read more here.
Keywords: parvalbumin positive; disruption kcc2; positive interneurons; loss ... See more keywords
Behavioral Alterations and Decreased Number of Parvalbumin-Positive Interneurons in Wistar Rats after Maternal Immune Activation by Lipopolysaccharide: Sex Matters
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063274
Abstract: Maternal immune activation (MIA) during pregnancy represents an important environmental factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to investigate the impacts of MIA on the brain and behavior… read more here.
Keywords: immune activation; maternal immune; positive interneurons; parvalbumin positive ... See more keywords