Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.8196
Abstract: Importance Amplification of ERBB2 (formerly referred to as HER2) is present in nearly 3% of patients with metastatic colorectal cancer overall and 5% of patients with KRAS and NRAS wild-type tumors. Despite the availability of… read more here.
Keywords: erbb2 positive; metastatic colorectal; positive metastatic; colorectal cancer ... See more keywords
Statin use in patients with hormone receptor‐positive metastatic breast cancer treated with everolimus and exemestane
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5369
Abstract: We analyzed the effect of statins in patients with hormone receptor‐positive (HR+) metastatic breast cancer treated with everolimus + exemestane (EverX). read more here.
Keywords: receptor positive; hormone receptor; positive metastatic; metastatic breast ... See more keywords
Radio-sensitising effect of T-DM1 should not be discarded for the efficacy of radiosurgery in the management of brain metastases in patients with HER2-positive metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2405-0
Abstract: 1. Geraud A, Xu HP, Beuzeboc P, Kirova YM (2016) Preliminary experience of the concurrent use of radiosurgery and T-DM1 for brain metastases in HER2-positive metastatic breast cancer. J Neurooncol 131:1–4 2. Adams SR, Yang… read more here.
Keywords: brain metastases; her2 positive; breast cancer; metastatic breast ... See more keywords
A case report on the long-term survival of a patient with HER2-positive metastatic gastric adenocarcinoma and a short review of the current literature
Sign Up to like & getrecommendations! Published in 2020 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-020-00649-2
Abstract: The prognosis of patients with metastatic gastroesophageal cancer remains poor despite numerous promising clinical trials, and the clinical benefit of systemic therapies is under critical review. This case report of a patient with human epidermal growth… read more here.
Keywords: metastatic gastric; her2 positive; gastric adenocarcinoma; review ... See more keywords
Phase III study to evaluate patient's preference of subcutaneous versus intravenous trastuzumab in HER2-positive metastatic breast cancer patients: Results from the ChangHER study (GEICAM/2012-07).
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer care"
DOI: 10.1111/ecc.13253
Abstract: OBJECTIVE We compared patients' preferences for intravenous (IV-t) versus subcutaneous (SC-t) trastuzumab administration. METHODS Phase III, open-label, multicentre study in HER2-positive metastatic breast cancer. Patients were receiving IV-t for at least 4 months without progression. Randomisation… read more here.
Keywords: preference; her2 positive; study; positive metastatic ... See more keywords
Treatment with pyrotinib-based therapy in lapatinib-resistant HER2-positive metastatic breast cancer: a multicenter real-world study
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359221085232
Abstract: Background: Tyrosine kinase inhibitors (TKIs) are effective for treating human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. However, therapies subsequent to TKI progression remain controversial, and effective treatments for TKI resistance are urgently… read more here.
Keywords: positive metastatic; pyrotinib based; based therapy; breast cancer ... See more keywords
Circulating PD-L1 (programmed death-ligand 1) and outcomes in a HER2-positive metastatic breast cancer cohort treated with first-line trastuzumab.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.1024
Abstract: 1024Background: Recently the immune checkpoint inhibitors (ICIs) have demonstrated efficacy across a wide variety of cancers, but have been less effective in breast cancer. PD-L1 (B7-H1, CD274) is a ligand produced by many tumor cells… read more here.
Keywords: her2 positive; positive metastatic; breast cancer; metastatic breast ... See more keywords
Pretreatment features and risk of death from BRAF-positive metastatic melanoma patients treated with vemurafenib.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e21028
Abstract: e21028Background: Clinicopathologic features of BRAF-positive metastatic melanoma patients were identified. No study to date has examined influence on risk of death features at baseline before starting treatment with vemurafenib. The purpose of the study is… read more here.
Keywords: melanoma; braf positive; death; metastatic melanoma ... See more keywords
Efficacy of CDK 4/6 inhibitors in ER positive metastatic breast cancer: Systematic review and meta-analysis of randomized clinical trials.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e13040
Abstract: e13040Background: The introduction of cyclin-dependent kinase (CDK) 4/6 inhibitors led to a significant paradigm shift in the management of Estrogen Receptor (ER) positive metastatic breast cancer (MBC). The purpose of this analysis was to evaluate… read more here.
Keywords: cdk inhibitors; inhibitors positive; analysis; breast cancer ... See more keywords
Utilization of anti-HER2 regimens among HER2-positive metastatic breast cancer patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.29_suppl.282
Abstract: 282Background: HER2-positive (+) metastatic breast cancer (mBC) has a poor prognosis and many patients require multiple lines of HER2 targeted regimens. This study aims to examine the treatment seq... read more here.
Keywords: positive metastatic; metastatic breast; her2 positive; breast cancer ... See more keywords
Overall Survival of Patients With ALK-Positive Metastatic Non–Small-Cell Lung Cancer in the Russian Federation: Nationwide Cohort Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Global Oncology"
DOI: 10.1200/jgo.19.00024
Abstract: PURPOSE The overall survival (OS) results in patients with ALK-positive metastatic non–small-cell lung cancer (NSCLC) have rarely been reported. The aim of this prospective-retrospective cohort study was to obtain real-world data on the use of… read more here.
Keywords: metastatic non; alk positive; cancer; positive metastatic ... See more keywords