Activity of telavancin against Gram-positive pathogens isolated from bone and joint infections in North American, Latin American, European and Asia-Pacific nations.
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.03.003
Abstract: Telavancin was tested against a worldwide collection of Gram-positive pathogens (967) isolated from bone and joint infections (BJI). Most BJI isolates were from the United States (US) (49.9%) followed by Europe (26.4%), Latin America (LATAM;… read more here.
Keywords: gram positive; telavancin; isolated bone; joint infections ... See more keywords
Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32829-w
Abstract: Small-molecule antivirulence agents represent a promising alternative or adjuvant to antibiotics. These compounds disarm pathogens of disease-causing toxins without killing them, thereby diminishing survival pressure to develop resistance. Here we show that the small-molecule antivirulence… read more here.
Keywords: gram positive; small molecule; antivirulence agents; positive pathogens ... See more keywords
Identification of a novel adjuvant loperamide that enhances the antibacterial activity of colistin against MCR-1-positive pathogens in vitro/vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Letters in applied microbiology"
DOI: 10.1093/lambio/ovad025
Abstract: Severe infection with MDR Enterobacterales caused by the plasmid-induced colistin resistance gene MCR-1 is a serious public health challenge. In this case, it is necessary and pressing to find a treatment to overcome antibiotic resistance.… read more here.
Keywords: loperamide; mcr positive; colistin; colistin mcr ... See more keywords
Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
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DOI: 10.1128/aac.01667-21
Abstract: Oritavancin displayed potent and stable activity (MIC90 range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets… read more here.
Keywords: methicillin resistant; positive pathogens; activity; gram positive ... See more keywords
Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00071
Abstract: The emergence and spread of carbapenemase in Gram-negative pathogens poses an enormous threat to global public health. New Delhi metallo-β-lactamase-1 (NDM-1) inactivates nearly every class of β-lactam antibiotics, including carbapenem; however, there is no clinically… read more here.
Keywords: embelin restores; ndm positive; efficacy ndm; carbapenem efficacy ... See more keywords
Synthesis and Development of N-2,5-Dimethylphenylthioureido Acid Derivatives as Scaffolds for New Antimicrobial Candidates Targeting Multidrug-Resistant Gram-Positive Pathogens
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12020220
Abstract: The growing antimicrobial resistance to last-line antimicrobials among Gram-positive pathogens remains a major healthcare emergency worldwide. Therefore, the search for new small molecules targeting multidrug-resistant pathogens remains of great importance. In this paper, we report… read more here.
Keywords: gram; targeting multidrug; activity; multidrug resistant ... See more keywords
Host–Pathogen Interactions of Marine Gram-Positive Bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11091316
Abstract: Simple Summary Complex interactions between marine Gram-positive pathogens and fish hosts in the marine environment can result in diseases of economically important finfish, which cause economic losses in the aquaculture industry. Understanding how these pathogens… read more here.
Keywords: marine gram; host pathogen; host; gram positive ... See more keywords
Does vancomycin administered at an empirical dose ensure coverage of pediatric patients against gram-positive pathogens?
Sign Up to like & getrecommendations! Published in 2020 at "Revista Brasileira de Terapia Intensiva"
DOI: 10.5935/0103-507x.20200067
Abstract: Objective To investigate the vancomycin effectiveness against gram-positive pathogens with the minimum inhibitory concentration of 1mg/L in pediatric patients based on the area under the curve and the minimum inhibitory concentration ratio > 400. Methods… read more here.
Keywords: minimum inhibitory; positive pathogens; inhibitory concentration; pediatric patients ... See more keywords