LncRNA GAS5 positively regulates IL‐10 expression in patients with generalized myasthenia gravis
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2457
Abstract: LncRNA growth arrest‐specific transcript 5 (GAS5) has been proven to be involved in autoimmune diseases. Rheumatoid arthritis is a type of autoimmune disease that may affect myasthenia gravis (MG) patients. However, its direct role in… read more here.
Keywords: myasthenia gravis; lncrna gas5; gas5; positively regulates ... See more keywords
AtOZF1 positively regulates JA signaling and SA-JA cross-talk in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biosciences"
DOI: 10.1007/s12038-021-00243-6
Abstract: Plant hormones regulate growth, development, and defense against biotic and abiotic stresses. Salicylic acid (SA), ethylene (ET), and jasmonate (JA) are major phytohormones that control the defense against pathogens. SA and JA primarily regulate resistance… read more here.
Keywords: atozf1; atozf1 positively; cross talk; arabidopsis ... See more keywords
Numb positively regulates autophagic flux via regulating lysosomal function.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.084
Abstract: Autophagy is a lysosome-dependent catabolic process involving in the degradation and recycling of unnecessary or damaged proteins and organelles. Emerging evidence indicates that autophagy dysfunction is closely related to various human diseases including cancer, aging,… read more here.
Keywords: numb depletion; regulates autophagic; numb positively; function numb ... See more keywords
DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.008
Abstract: Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial… read more here.
Keywords: cells dyrk1a; dyrk1a kinase; angiogenic responses; endothelial cells ... See more keywords
The stringent response factor, RelA, positively regulates T6SS4 expression through the RovM/RovA pathway in Yersinia pseudotuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiological research"
DOI: 10.1016/j.micres.2018.12.002
Abstract: The type VI secretion system (T6SS) is a versatile molecular machinery widely distributed in Gram-negative bacteria. The activity of the T6SS is tightly regulated by various mechanisms, including quorum sensing (QS), iron concentration, and transcriptional… read more here.
Keywords: response; stringent response; rela positively; expression ... See more keywords
Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101453
Abstract: Currently, most antioxidants do not show any favorable clinical outcomes in reducing myocardial ischemia-reperfusion (I/R) injury, suggesting an urgent need for exploring a new regulator of redox homeostasis in I/R hearts. Here, using heart-specific transgenic… read more here.
Keywords: p62 keap1; keap1 nrf2; tsg101 positively; positively regulates ... See more keywords
SlMAPK3 Positively Regulates the Ethylene Production of Postharvest Tomato Fruits and Is Involved in Ethylene-Mediated Cold Tolerance.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08723
Abstract: Mitogen-activated protein kinase (MAPK) cascades and ethylene are crucial for plant growth, development, and stress responses, but their potential mechanisms in cold resistance remain unclear. We revealed that SlMAPK3 transcript levels were dramatically induced by… read more here.
Keywords: slmapk3; regulates ethylene; production postharvest; positively regulates ... See more keywords
The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjx036
Abstract: The Hedgehog (Hh) signaling pathway plays important roles in developmental processes including pattern formation and tissue homeostasis. The seven-pass transmembrane receptor Smoothened (Smo) is the pivotal transducer in the pathway; it, and thus the pathway… read more here.
Keywords: hedgehog signaling; regulates hedgehog; deubiquitinase uchl5; uch37 positively ... See more keywords
The Apple BTB Protein MdBT2 Positively Regulates MdCOP1 Abundance to Repress Anthocyanin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac279
Abstract: The ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays a central role in light-induced anthocyanin biosynthesis. However, the upstream regulatory factors of COP1 remain poorly understood, particularly in horticultural plants. Here, we identified a MdCOP1-interacting protein,… read more here.
Keywords: btb protein; biosynthesis; regulates mdcop1; positively regulates ... See more keywords
USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13552
Abstract: The relative abundance of myeloid‐derived suppressor cells (MDSCs) compared to cytotoxic T cells determines the outcomes of diseases and the efficacy of immunotherapy. Ubiquitin‐specific peptidase 12 (USP12), a member of the USP family of deubiquitinases,… read more here.
Keywords: function; mdscs; stabilizing p65; positively regulates ... See more keywords
HBI1-TCP20 interaction positively regulates the CEPs-mediated systemic nitrate acquisition.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13035
Abstract: Nitrate is the main source of nitrogen for plants but often distributed heterogeneously in soil. Plants have evolved sophisticated strategies to achieve adequate nitrate by modulating the root system architecture. The nitrate acquisition system is… read more here.
Keywords: tcp20 interaction; hbi1 tcp20; positively regulates; systemic nitrate ... See more keywords