PGA: post-GWAS analysis for disease gene identification
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx845
Abstract: Summary Although the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and… read more here.
Keywords: post gwas; disease gene; disease; gwas ... See more keywords
Genetics of coronary artery disease in the post‐GWAS era
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13362
Abstract: During the past decade, genome‐wide association studies (GWAS) have transformed our understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now further markedly expand the knowledge on coronary artery disease (CAD) genetics in doubling… read more here.
Keywords: medicine; post gwas; genetics; coronary artery ... See more keywords
A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility
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DOI: 10.1371/journal.pone.0174738
Abstract: Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) with variants previously implicated in TB disease susceptibility. The probability that these… read more here.
Keywords: tuberculosis susceptibility; post gwas; predicted regulatory; regulatory variants ... See more keywords
Benchmarking post-GWAS analysis tools in major depression: Challenges and implications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1006903
Abstract: Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS). However, we do not understand yet… read more here.
Keywords: gwas analysis; post; post gwas; major depression ... See more keywords
The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update
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DOI: 10.3390/genes14020405
Abstract: Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among autoimmune diseases, which are polygenic complex traits caused by the combined… read more here.
Keywords: primary biliary; biliary cholangitis; gwas; post gwas ... See more keywords