KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway.
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DOI: 10.1016/j.cellsig.2019.109415
Abstract: It has been reported that KDM3A participates in several cardiovascular diseases through epigenetic mechanisms. However, its biological role post myocardial infarction (MI) has not been explored. Excessive and prolonged inflammation period can aggravate post-MI injuries… read more here.
Keywords: macrophage polarization; post injuries; polarization; post ... See more keywords