Cardioprotection of post-ischemic moderate ROS against ischemia/reperfusion via STAT3-induced the inhibition of MCU opening
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0747-9
Abstract: Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH)-afforded cardioprotection against ischemia/reperfusion (I/R). However, its mechanism remains largely unknown. This… read more here.
Keywords: h2o2poc; mcu; post ischemic; moderate h2o2poc ... See more keywords
The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0605-6
Abstract: Ischemic stroke is a debilitating multi-factorial cerebrovascular disorder, representing an area of tremendous unmet medical need. Combination treatment has been proposed as a promising therapeutic approach towards combating ischemic stroke. The present study employs in… read more here.
Keywords: combination; post ischemic; treatment; paroxetine ... See more keywords
Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.10.006
Abstract: Background Acute kidney injury (AKI) may lead to the development of chronic kidney disease (CKD), i.e. AKI-CKD transition, but the underlying mechanism remains largely unclear. Endoplasmic reticulum (ER) stress is characterized by the accumulation of… read more here.
Keywords: chronic kidney; post ischemic; ckd transition; stress ... See more keywords
Increased Cysteine Sulfonation of the Hydrophilic Domain of Complex I Mediates Mitochondrial Dysfunction in the Post-ischemic Heart
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.170
Abstract: A serious consequence of ischemia-reperfusion injury (I/R) is oxidative damage leading to mitochondrial dysfunction. Such I/R-induced mitochondrial dysfunction is observed as impaired state 3 respiration, decreased ATP generation, and overproduction of O2. The cascading ROS… read more here.
Keywords: complex mediates; post ischemic; dysfunction; sulfonation ... See more keywords
T cells in the post-ischemic brain: Troopers or paramedics?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.11.006
Abstract: The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies… read more here.
Keywords: cells post; post ischemic; brain troopers; troopers paramedics ... See more keywords
Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.08.006
Abstract: RATIONALE Among its many biological roles, fibroblast growth factor 2 (FGF2) protects the heart from dysfunction and damage associated with an ischemic attack. Our laboratory demonstrated that its protection against myocardial dysfunction occurs by the… read more here.
Keywords: fgf2; lmw fgf2; hearts expressing; post ischemic ... See more keywords
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2104405
Abstract: Abstract Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents… read more here.
Keywords: lipidic nanocapsules; post ischemic; nose brain; brain delivery ... See more keywords
FC 042IRF8 IN CDC1 IS PROTECTIVE IN POST-ISCHEMIC ACUTE KIDNEY INJURY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab119.002
Abstract: Post-ischemic acute tubular necrosis is a common cause of acute kidney disease (AKD) and subsequent chronic kidney disease. In AKD, mononuclear phagocytes (MPCs) including conventional dendritic cells (cDCs) are present during the different phases of… read more here.
Keywords: akd; injury; kidney; irf8 ... See more keywords
831: EFFECTS OF LONG-TERM POST-ISCHEMIC TREADMILL EXERCISE ON GLIOSIS IN THE AGED GERBIL HIPPOCAMPUS
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528840.20754.82
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Therapeutic exercise is an integral component of the rehabilitation of patients with stroke. The objective of the present study was to investigate… read more here.
Keywords: medicine; post ischemic; treadmill exercise; exercise ... See more keywords
Inhibition of TRPC6 promotes capillary arterialization during post-ischemic blood flow recovery.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15942
Abstract: BACKGROUND AND PURPOSE Capillary arterialization, characterized by the coverage of pre-existing or nascent capillary vessels with vascular smooth muscle cells (VSMCs), is critical for the development of collateral arterioles to improve post-ischemic blood flow. We… read more here.
Keywords: blood; blood flow; flow recovery; post ischemic ... See more keywords
Abstract MP150: Inositol 1,4,5-trisphosphate Receptors Selectively Regulate Detrimental Cardiac Fibrosis by Modulating ER-phagy
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.mp150
Abstract: Background: Therapeutic strategies that specifically target excessive post-ischemic cardiac fibrosis are lacking but desperately needed; thus, it is critical to understand the molecular mechanisms underlying these processes. Genome-wide association studies have revealed an association between… read more here.
Keywords: trisphosphate receptors; fibrosis; post ischemic; ischemic cardiac ... See more keywords