Understanding post-mitotic roles of the midbody during cell differentiation and polarization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.04.001
Abstract: The midbody (MB) is a microtubule-rich structure that forms between dividing cells during final stages of cytokinesis. Previously thought to be a transient structure, MBs are now suggested to have additional roles beyond regulating cytokinesis.… read more here.
Keywords: midbody; post mitotic; understanding post; mitotic roles ... See more keywords
Long-lived post-mitotic cell aging: is a telomere clock at play?
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111256
Abstract: Senescence is a cellular response to stress for both dividing and post-mitotic cells. Noteworthy, long-lived post-mitotic cells (collectively named LLPMCs), which can live for decades in the organism, can exhibit a distinct type of cellular… read more here.
Keywords: telomere clock; lived post; post mitotic; post ... See more keywords
In vivo base editing of post-mitotic sensory cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04580-3
Abstract: Programmable nucleases can introduce precise changes to genomic DNA through homology-directed repair (HDR). Unfortunately, HDR is largely restricted to mitotic cells, and is typically accompanied by an excess of stochastic insertions and deletions (indels). Here… read more here.
Keywords: base editing; editing post; post mitotic; base ... See more keywords
RPA shields inherited DNA lesions for post-mitotic DNA synthesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23806-5
Abstract: The paradigm that checkpoints halt cell cycle progression for genome repair has been challenged by the recent discovery of heritable DNA lesions escaping checkpoint control. How such inherited lesions affect genome function and integrity is… read more here.
Keywords: mitotic dna; dna synthesis; dna; dna lesions ... See more keywords
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28358-w
Abstract: Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome - mitochondrial… read more here.
Keywords: adeno associated; post mitotic; base; base editing ... See more keywords
DNMT1 regulates expression of MHC class I in post-mitotic neurons
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Brain"
DOI: 10.1186/s13041-018-0380-9
Abstract: Major Histocompability Complex I (MHC-I) molecules present cellularly derived peptides to the adaptive immune system. Generally MHC-I is not expressed on healthy post-mitotic neurons in the central nervous system, but it is known to increase… read more here.
Keywords: mitotic neurons; post mitotic; expression; dnmt1 ... See more keywords
Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007691
Abstract: Post-mitotic cell separation is one of the most prominent events in the life cycle of eukaryotic cells, but the molecular underpinning of this fundamental biological process is far from being concluded and fully characterized. We… read more here.
Keywords: mitotic cell; saccharomyces cerevisiae; post mitotic; cell separation ... See more keywords
Nuclear Prospero allows one-division potential to neural precursors and post-mitotic status to neurons via opposite regulation of Cyclin E
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010339
Abstract: In Drosophila embryonic CNS, the multipotential stem cells called neuroblasts (NBs) divide by self-renewing asymmetric division and generate bipotential precursors called ganglion mother cells (GMCs). GMCs divide only once to generate two distinct post-mitotic neurons.… read more here.
Keywords: prospero; division potential; mitotic status; cyclin ... See more keywords
A gene subset requires CTCF bookmarking during the fast post‐mitotic reactivation of mouse ES cells
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202256075
Abstract: Mitosis leads to global downregulation of transcription that then needs to be efficiently resumed. In somatic cells, this is mediated by a transient hyper‐active state that first reactivates housekeeping and then cell identity genes. Here,… read more here.
Keywords: cell; reactivation; post mitotic; mitotic bookmarking ... See more keywords