Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo
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DOI: 10.15252/emmm.202115415
Abstract: Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a… read more here.
Keywords: inflammation; asc specks; post pyroptotic; nanobodies dismantle ... See more keywords