Antidiabetic Properties of Low-Molecular-Weight BDNF Mimetics Depend on the Type of Activation of Post-Receptor Signaling Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4069-y
Abstract: Reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (BDNF). Low-molecular weight compounds similar to different BDNF loops were synthesized at the V. V.… read more here.
Keywords: signaling pathways; post receptor; low molecular; molecular weight ... See more keywords
The neural retina in retinopathy of prematurity
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2016.09.004
Abstract: ABSTRACT Retinopathy of prematurity (ROP) is a neurovascular disease that affects prematurely born infants and is known to have significant long term effects on vision. We conducted the studies described herein not only to learn… read more here.
Keywords: post receptor; disease; rop; retinopathy prematurity ... See more keywords
Abstract 142: Purinergic P2 X Receptors and a T 1 Receptors Share Post - Receptor Signaling Pathways Regulating Renal Afferent Arterioles in Angiotensin I I ( Ang I I) Dependent Hypertension
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DOI: 10.1161/hyp.74.suppl_1.142
Abstract: In Ang II dependent hypertension, the increased afferent arteriolar resistance (AAR) is assumed to be primarily due to the increased intrarenal levels of Ang II activating AT1 receptors. Because the renal interstitial ATP levels increase… read more here.
Keywords: signaling pathways; post receptor; dependent hypertension; ang dependent ... See more keywords
Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle
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DOI: 10.1371/journal.pone.0184987
Abstract: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders caused by expansion of microsatellite repeats. In both forms, the mutant transcripts accumulate in nuclear foci altering the function of alternative… read more here.
Keywords: insulin; post receptor; type; insulin resistance ... See more keywords
Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction
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DOI: 10.3390/ijms19071843
Abstract: The growth hormone (GH) plays a key role in the regulation of metabolic processes in an organism. Determination of the correct structure and functioning of the growth hormone receptor (GHR) allowed for a more detailed… read more here.
Keywords: receptor; growth hormone; post receptor; receptor inhibitors ... See more keywords