Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities
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DOI: 10.1016/j.ebiom.2020.103044
Abstract: Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so does the number of sepsis survivors who suffer from “post-sepsis syndrome” after hospital discharge. This syndrome involves deficits in multiple… read more here.
Keywords: sepsis; therapeutic opportunities; pathophysiology; post sepsis ... See more keywords
GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL
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DOI: 10.1097/shk.0000000000002030
Abstract: ABSTRACT Significant numbers of patients who survive sepsis exhibit psychiatric and cognitive impairments, termed post-sepsis syndrome. Understanding the underlying pathophysiology is essential to develop effective therapies. Translocator protein 18 kDa (TSPO) is a multifaceted mitochondrial… read more here.
Keywords: sepsis; c1q pathway; sepsis syndrome; post sepsis ... See more keywords
Association between Adherence to Recommended Care and Outcomes for Adult Survivors of Sepsis.
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DOI: 10.1513/annalsats.201907-514oc
Abstract: RATIONALE Post-sepsis care recommendations target specific deficits experienced by sepsis survivors, including optimizing medications, screening for functional impairments, monitoring for common and preventable causes for health deterioration, and consideration of palliative care. However, there are… read more here.
Keywords: care; health; sepsis; post sepsis ... See more keywords
Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications
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DOI: 10.3389/fcvm.2023.1076745
Abstract: Background Patients with sepsis are at increased risk for cardiovascular complications, including myocardial infarction (MI), ischemic stroke (IS), and venous thromboembolism (VTE). Our objective is to assess whether genetic risk score (GRS) can differentiate risk… read more here.
Keywords: sepsis; sepsis cardiovascular; risk; cardiovascular complications ... See more keywords
Prolonged Transcriptional Consequences in Survivors of Sepsis
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DOI: 10.3390/ijms22115422
Abstract: Survivors of sepsis often suffer from prolonged post-critical illness syndrome secondary to the immune system’s reprogramming. It is unclear if this process is static and pervasive due to methodological difficulties studying long-term outcomes of sepsis.… read more here.
Keywords: sepsis; prolonged transcriptional; drosophila melanogaster; survivors sepsis ... See more keywords