Sodium channel subtypes are differentially localized to pre‐ and post‐synaptic sites in rat hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24291
Abstract: Voltage‐gated Na+ channels (Nav) modulate neuronal excitability, but the roles of the various Nav subtypes in specific neuronal functions such as synaptic transmission are unclear. We investigated expression of the three major brain Nav subtypes… read more here.
Keywords: nav subtypes; axon terminals; pre post; rat hippocampus ... See more keywords
Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24369
Abstract: Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization-mediated loss of NMDARs is thought to be the major… read more here.
Keywords: nr1 autoantibody; nmda receptors; autoantibody; synaptic proteins ... See more keywords
Specific motifs mediate post-synaptic and surface transport of G protein-coupled receptors
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2021.103643
Abstract: Summary G protein-coupled receptors (GPCRs) are key regulators of synaptic functions. However, their targeted trafficking to synapses after synthesis is poorly understood. Here, we demonstrate that multiple motifs mediate α2B-adrenergic receptor transport to the dendritic… read more here.
Keywords: post synaptic; coupled receptors; protein coupled; post ... See more keywords
Pronounced and sustained cutaneous vasoconstriction during and following cyrotherapy treatment: Role of neurotransmitters released from sympathetic nerves.
Sign Up to like & getrecommendations! Published in 2018 at "Microvascular research"
DOI: 10.1016/j.mvr.2017.08.005
Abstract: Cryotherapy is a therapeutic technique using ice or cold water applied to the skin to manage soft tissue trauma and injury. While beneficial, there are some potentially detrimental side effects, such as pronounced vasoconstriction and… read more here.
Keywords: treatment; site; vasoconstriction; synaptic adrenergic ... See more keywords
Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.01.044
Abstract: The human ANKS1B gene encodes an activity-dependent effector of post-synaptic signaling. It was recently associated with neuropsychiatric phenotypes in genome-wide studies. While the biological function of ANKS1B has been partly elucidated, its role in behavior… read more here.
Keywords: response; ketamine; effector; anks1b ... See more keywords
All the brain's a stage for serotonin: the forgotten story of serotonin diffusion across cell membranes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2022.1565
Abstract: In the conventional model of serotonin neurotransmission, serotonin released by neurons in the midbrain raphe nuclei exerts its actions on forebrain neurons by interacting with a large family of post-synaptic receptors. The actions of serotonin… read more here.
Keywords: cell membranes; serotonin; diffusion; brain ... See more keywords
Abstract 31: CaMKII-alpha Ubiquitination Induced by Cerebral Ischemia-Reperfusion Injury Reversibly Inhibits Post-Ischemic CaMKII Activity at the Post-Synaptic Density
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/str.49.suppl_1.31
Abstract: Background: Brain calcium-calmodulin-dependent protein kinase II (CaMKII) is exclusively expressed in neurons, where it localizes to the post-synaptic density (PSD) to link calcium signals to chang... read more here.
Keywords: camkii; abstract camkii; post; synaptic density ... See more keywords
Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0812-5
Abstract: A hexanucleotide repeat expansion in a noncoding region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Reduction of select or total C9orf72 transcript and protein levels… read more here.
Keywords: c9orf72; localization; receptor levels; post synaptic ... See more keywords
Transgenerational Bisphenol A causes deficits in social recognition and alters post-synaptic density genes in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/en.2019-00196
Abstract: Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical (EDC). Developmental exposure produces changes in behavior and gene expression in brain. Here we examined social recognition behaviors in mice, three generations (F3) after exposure to gestational… read more here.
Keywords: bisphenol; bpa; expression; social recognition ... See more keywords
CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010211
Abstract: Changes in neurotransmitter receptor abundance at post-synaptic elements play a pivotal role in regulating synaptic strength. For this reason, there is significant interest in identifying and characterizing the scaffolds required for receptor localization at different… read more here.
Keywords: classes post; two classes; transmission; post synaptic ... See more keywords
A Novel CNTNAP2 Mutation Results in Abnormal Neuronal E/I Balance
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.712773
Abstract: CNTNAP2 (coding for protein Caspr2), a member of the neurexin family, plays an important role in the balance of excitatory and inhibitory post-synaptic currents (E/I balance). Here, we describe a novel pathogenic missense mutation in… read more here.
Keywords: mutation; synaptic currents; cntnap2 r777g; balance ... See more keywords