Osmium Tag for Post‐transcriptionally Modified RNA
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DOI: 10.1002/cbic.201800274
Abstract: 5‐Methylcytidine (m5C) and 5‐methyluridine (m5U) are highly abundant post‐transcriptionally modified nucleotides that are observed in various natural RNAs. Such nucleotides were labeled through a chemical approach, as both underwent oxidation at the C5=C6 double bond,… read more here.
Keywords: osmium tag; post transcriptionally; osmium; transcriptionally modified ... See more keywords
Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.05.011
Abstract: Summary Epithelial-to-mesenchymal transition (EMT) is integral to cancer progression, with considerable evidence that EMT has multiple intermediary stages. Understanding the mechanisms of this stepwise activation is of great interest. We recreated a genetically defined model… read more here.
Keywords: post transcriptionally; invasion; transcriptionally enhances; protein abundance ... See more keywords
tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.066126.118
Abstract: tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are abundant small RNAs reported to be associated with Argonaute proteins, yet their function is unclear. We show that endogenous 18 nucleotide tRFs derived… read more here.
Keywords: post transcriptionally; dicer independent; trf; trna fragments ... See more keywords
MiR-199a/b-5p inhibits hepatocellular carcinoma progression by post-transcriptionally suppressing ROCK1
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DOI: 10.18632/oncotarget.18052
Abstract: In this study, we explored the actions of miR-199a/b-5p during hepatocellular carcinoma (HCC) progression and its potential target genes. Through heatmap miRNA expression analysis of 15 matched HCC tumor and adjacent non-tumor liver tissues from… read more here.
Keywords: hepatocellular carcinoma; post transcriptionally; hcc; mir 199a ... See more keywords