Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02230-x
Abstract: While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the… read more here.
Keywords: postmortem brain; human postmortem; pathology; brain analyses ... See more keywords
Enrichment of rare genetic variants in astrocyte gene enriched co-expression modules altered in postmortem brain samples of schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.10.013
Abstract: The transcriptome profiles of the cingulate gyrus region from the postmortem brain tissues of a set of well-characterized patients with schizophrenia (SCZ) and matched controls were investigated using an integrated approach that analyzed both the… read more here.
Keywords: postmortem brain; genetic variants; expression modules; expression ... See more keywords
Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41572-9
Abstract: Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of lactate energetically couples astrocytes and neurons and supports brain bioenergetics. We examined the concentration… read more here.
Keywords: schizophrenia; postmortem brain; lactate; animal models ... See more keywords
S182. HISTONE H3 AND H4 POST-TRANSLATIONAL REGULATION IN SCHIZOPHRENIA POSTMORTEM BRAIN: EFFECT OF ANTIPSYCHOTIC TREATMENT
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa031.248
Abstract: Abstract Background Epigenetic modifications recording obstetrical adverse events are a fundamental component of the neurodevelopmental hypothesis of schizophrenia (SZ). Epigenome-wide association studies performed in peripheral tissues samples of first-episode cases or young population at high… read more here.
Keywords: schizophrenia; postmortem brain; post translational; brain ... See more keywords
Differential H3K9me2 heterochromatin levels and concordant mRNA expression in postmortem brain tissue of individuals with schizophrenia, bipolar, and controls
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1006109
Abstract: The existence of repressive and durable chromatin assemblies along gene promoters or networks, especially in the brain, is of theoretical and therapeutic relevance in a subset of individuals diagnosed with schizophrenia who experience a chronic,… read more here.
Keywords: postmortem brain; brain; brain tissue; mrna expression ... See more keywords