POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507951
Abstract: Tendinous heterotopic ossification can cause pain and restricted joint mobility in affected areas, and it is a common and severe complication following tendon injuries. This condition significantly reduces the postoperative quality of life of patients,… read more here.
Keywords: traumatic heterotopic; heterotopic; heterotopic ossification; tendon derived ... See more keywords
Spatial Transcriptomics and snRNA-seq Expose CAF Niches Orchestrating Dual Stromal-Immune Barriers in Hepatocellular Carcinoma.
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DOI: 10.1002/advs.202514661
Abstract: Hepatocellular carcinoma (HCC) exhibits profound spatial heterogeneity driving therapeutic resistance, while the role of cancer‐associated fibroblasts (CAFs) in orchestrating immunosuppressive niches remains incompletely defined. This study integrates single‐nucleus RNA sequencing (snRNA‐seq) and spatial transcriptomics (stRNA‐seq)… read more here.
Keywords: snrna seq; spatial transcriptomics; hepatocellular carcinoma; cell ... See more keywords
Cancer cell‐derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5601
Abstract: It recently has been reported that partial‐epithelial–mesenchymal transition (p‐EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion‐promoting molecule in… read more here.
Keywords: cell; postn; iso5; isoform ... See more keywords
POSTN promotes diabetic vascular calcification by interfering with autophagic flux.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109983
Abstract: Autophagy is a lysosomal degradative process that is closely related to the pathogenesis of vascular calcification. Recent evidence suggests that periostin (POSTN) is a unique extracellular matrix protein that is associated with diabetic vascular complications.… read more here.
Keywords: diabetic vascular; vascular calcification; postn; calcification ... See more keywords
Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer
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DOI: 10.1016/j.tranon.2020.100789
Abstract: Periostin (POSTN) is an extracellular matrix protein associated with tumor progression and shorter survival in prostate cancer (PCa). Here, we performed an integrative analysis of POSTN’s role in patients with PCa. Clinical and POSTN data… read more here.
Keywords: integrative analysis; analysis; postn; prostate cancer ... See more keywords
miR-876 Inhibits EMT and Liver Fibrosis via POSTN to Suppress Metastasis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/1964219
Abstract: Background The asymptomatic onset, frequent recurrence, and poor prognosis of hepatocellular carcinoma (HCC) prompted us to identify new therapeutic targets or predictive markers of HCC diagnosis or prognosis. Methods In this study, bioinformatics analysis was… read more here.
Keywords: hepatocellular carcinoma; mir 876; hcc; fibrosis ... See more keywords
Abstract 2568: Cancer-associated fibroblasts-derived periostin promotes lymph node metastasis of cholangiocarcinoma through lymphatic endothelial reprogramming
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2568
Abstract: Cholangiocarcinoma (CCA) is a bile duct malignancy with poor outcomes, especially in patients with lymph node metastasis (LNM). However, the mechanism of LNM in CCA as well as its therapeutic options remain undefined. Understanding crosstalk… read more here.
Keywords: cca; cancer; culture; lymph node ... See more keywords
Abstract 521: Cardiac Fibroblasts are Activated During Postnatal Extracellular Matrix Remodeling
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.521
Abstract: Objectives: During the postnatal period, P0 to P30 in the mouse, the myocardial extracellular matrix (ECM) transitions to a mature profile necessary for increased cardiac output. We hypothesize that, during the postnatal period, cardiac fibroblasts… read more here.
Keywords: mcm r26; postn; r26 gfp; mcm ... See more keywords
Identification of Postn+ periosteal progenitor cells with bone regenerative potential
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DOI: 10.1172/jci.insight.182524
Abstract: Bone contains multiple pools of skeletal stem/progenitor cells (SSPCs), and SSPCs in periosteal compartments are known to exhibit higher regenerative potential than those in BM and endosteal compartments. However, the in vivo identity and hierarchical… read more here.
Keywords: sspcs sspcs; identification postn; regenerative potential; progenitor cells ... See more keywords
Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-025-03335-4
Abstract: Intervertebral disc degeneration (IDD) is a leading cause of low back pain, often linked to inflammation and pyroptosis in nucleus pulposus (NP) cells. The role of Periostin (POSTN) in IDD remains unclear. This study aims… read more here.
Keywords: disc degeneration; intervertebral disc; nucleus pulposus; pyroptosis ... See more keywords
Salivary and serum periostin in kidney transplant recipients
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DOI: 10.1371/journal.pone.0285256
Abstract: Introduction End-stage renal disease (ESRD) treatment includes dialysis and kidney transplantation. Transplant rejection is a major barrier to transplant success. One of the markers mentioned in previous studies on renal function in patients with renal… read more here.
Keywords: salivary serum; serum; postn; kidney transplant ... See more keywords