The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: an in-depth review
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DOI: 10.1080/07853890.2024.2411012
Abstract: Abstract Postoperative neurocognitive disorders (PND) are the most common neurological disorders following surgery and anaesthesia before and within 12 months after surgery, with a high prevalence in the geriatric population. PND can severely deteriorate the quality… read more here.
Keywords: postoperative neurocognitive; homeostasis; mechanism mitochondrial; mitochondrial homeostasis ... See more keywords
Hippocampal Nogo66‐NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders
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DOI: 10.1111/acel.14366
Abstract: Postoperative neurocognitive disorders (pNCD) are a common neurological complication, especially in elderly following anesthesia and surgery. Yet, the underlying mechanisms of pNCD remain elusive. This study aimed to investigate the molecular mechanisms that compromise synaptic… read more here.
Keywords: hippocampal nogo66; postoperative neurocognitive; aged mice; nogo66 ngr1 ... See more keywords
Interventions to prevent postoperative neurocognitive complications: an umbrella review of meta-analyses of randomised controlled trials.
Sign Up to like & getrecommendations! Published in 2025 at "Anaesthesia"
DOI: 10.1111/anae.70061
Abstract: INTRODUCTION The certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence… read more here.
Keywords: postoperative neurocognitive; meta analyses; analyses randomised; neurocognitive complications ... See more keywords
Heterogeneous nuclear ribonucleoprotein A2/B1 as a novel biomarker in elderly patients for the prediction of postoperative neurocognitive dysfunction: A prospective nested case-control study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1034041
Abstract: Background and objective Postoperative neurocognitive dysfunction (PND) occurs in up to 54% of older patients, giving rise to the heavy psychological and economic burdens to patients and society. To date, the development of PND biomarkers… read more here.
Keywords: elderly patients; heterogeneous nuclear; postoperative neurocognitive; nuclear ribonucleoprotein ... See more keywords
A novel predictive strategy for the incidence of postoperative neurocognitive dysfunction in elderly patients with mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.985406
Abstract: Objective: Preoperative levels of cognition-related biomarkers and intraoperative cerebral ischemia and hypoxia might cause postoperative neurocognitive dysfunction (PND). The aim of this study was to evaluate the predictive ability of preoperative plasma biomarkers along with… read more here.
Keywords: elderly patients; mild cognitive; postoperative neurocognitive; cognitive impairment ... See more keywords
Transcranial near-infrared laser improves postoperative neurocognitive disorder in aged mice via SIRT3/AMPK/Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1100915
Abstract: Background Postoperative neurocognitive disorder (PND) is a common central nervous system (CNS) complication that might increase the morbidity and mortality of elderly patients after anesthesia/surgery. Neuroinflammation, oxidative stress, and synaptic dysfunction are closely related to… read more here.
Keywords: infrared laser; laser; postoperative neurocognitive; near infrared ... See more keywords
Low-Intensity Pulsed Ultrasound Attenuates Postoperative Neurocognitive Impairment and Salvages Hippocampal Synaptogenesis in Aged Mice
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DOI: 10.3390/brainsci13040657
Abstract: Postoperative neurocognitive impairment is an urgent problem with global aging accelerating. The prevention and treatment of postoperative neurocognitive impairment have been widely investigated but lack effective strategies. Low-intensity pulsed ultrasound (LIPUS), a non-invasive tool, has… read more here.
Keywords: lipus; postoperative neurocognitive; impairment; aged mice ... See more keywords
Postoperative neurocognitive disorders
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DOI: 10.4097/kja.20294
Abstract: A decline in cognitive function is a frequent complication of major surgery. Postoperative cognitive impairments have generally been divided into short- (postoperative delirium) and long-term disturbances (postoperative cognitive dysfunction [POCD]). Long-term impairments are often subtle… read more here.
Keywords: postoperative cognitive; postoperative neurocognitive; cognitive function; pocd ... See more keywords
The effects of early postoperative neurocognitive disorders on clinically relevant outcomes: a meta-analysis.
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DOI: 10.4097/kja.23126
Abstract: Background Early postoperative neurocognitive disorders (ePND) include emergence delirium, defined as a very early onset postoperative delirium, and emergence agitation, defined as motor arousal. These ways of anesthesia emergence are poorly investigated although they are… read more here.
Keywords: meta analysis; postoperative neurocognitive; delirium; early postoperative ... See more keywords
Effect of prophylactic corticosteroids on postoperative neurocognitive dysfunction in the adult population: An updated systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials
Sign Up to like & getrecommendations! Published in 2024 at "Indian Journal of Anaesthesia"
DOI: 10.4103/ija.ija_149_24
Abstract: Background and Aims: Postoperative neurocognitive dysfunction (PNCD) commonly occurs after surgery and prolongs hospital stays. Both direct noxious stimuli to the central nervous system and systemic inflammation have been implicated. Due to their potent anti-inflammatory… read more here.
Keywords: postoperative neurocognitive; meta analysis; systematic review; analysis ... See more keywords