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   Articles with "postsynaptic density" as a keyword



Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.06.047

Abstract: Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction compartments responsible for signal processing in each and every neuron. Proper formation and dynamic responses to stimulations of synapses, both during development and in adult, are fundamental to… read more here.

Keywords: molecular platform; platform understanding; postsynaptic density; formation ... See more keywords
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Supramolecular organization of NMDA receptors and the postsynaptic density

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recommendations! Published in 2017 at "Current opinion in neurobiology"

DOI: 10.1016/j.conb.2017.05.019

Abstract: The postsynaptic density (PSD) of all vertebrate species share a highly complex proteome with ~1000 conserved proteins that function as sophisticated molecular computational devices. Here, we review recent studies showing that this complexity can be… read more here.

Keywords: organization nmda; nmda receptors; supramolecular organization; postsynaptic density ... See more keywords

FAM81A protein, a novel component of the postsynaptic density in adult brain

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.02.003

Abstract: Analysis of affinity-purified PSD-95 complexes had previously identified a 'hypothetical protein', product of the gene FAM81A [1]. The present study examined the tissue and subcellular distribution of FAM81A protein and its expression levels during development.… read more here.

Keywords: protein; adult brain; fam81a protein; postsynaptic density ... See more keywords

Tubulin and GTP Are Crucial Elements for Postsynaptic Density Construction and Aggregation

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recommendations! Published in 2025 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.70085

Abstract: In our previous experiments on the postsynaptic density lattice (PSDL), which is thought to serve as the backbone structure for the PSD, we suggested that tubulin plays a fundamental role in the PSD structure at… read more here.

Keywords: postsynaptic density; tubulin; construction; aggregation ... See more keywords

Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)–Mas on cerebral ischaemia injury

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recommendations! Published in 2022 at "Stroke and Vascular Neurology"

DOI: 10.1136/svn-2021-001396

Abstract: Background Postsynaptic density protein-95 (PSD95) plays an important role in cerebral ischaemia injury, but its mechanism needs further research. This study aimed to explore the role of PSD95 in (Ang-(1-7))-Mas-mediated cerebral ischaemia protection and its… read more here.

Keywords: density protein; postsynaptic density; psd95; ang mas ... See more keywords
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Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices

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recommendations! Published in 2021 at "Life Science Alliance"

DOI: 10.26508/lsa.202000945

Abstract: This study proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins. A purification protocol was developed to identify… read more here.

Keywords: non microtubule; postsynaptic density; psd; tubulin ... See more keywords

Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders

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recommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2024.1359154

Abstract: A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD) signaling hub, with many variants… read more here.

Keywords: signaling hub; psd signaling; tnik; postsynaptic density ... See more keywords