Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.047
Abstract: Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction compartments responsible for signal processing in each and every neuron. Proper formation and dynamic responses to stimulations of synapses, both during development and in adult, are fundamental to… read more here.
Keywords: molecular platform; platform understanding; postsynaptic density; formation ... See more keywords
Supramolecular organization of NMDA receptors and the postsynaptic density
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in neurobiology"
DOI: 10.1016/j.conb.2017.05.019
Abstract: The postsynaptic density (PSD) of all vertebrate species share a highly complex proteome with ~1000 conserved proteins that function as sophisticated molecular computational devices. Here, we review recent studies showing that this complexity can be… read more here.
Keywords: organization nmda; nmda receptors; supramolecular organization; postsynaptic density ... See more keywords
FAM81A protein, a novel component of the postsynaptic density in adult brain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.02.003
Abstract: Analysis of affinity-purified PSD-95 complexes had previously identified a 'hypothetical protein', product of the gene FAM81A [1]. The present study examined the tissue and subcellular distribution of FAM81A protein and its expression levels during development.… read more here.
Keywords: protein; adult brain; fam81a protein; postsynaptic density ... See more keywords
Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)–Mas on cerebral ischaemia injury
Sign Up to like & getrecommendations! Published in 2022 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2021-001396
Abstract: Background Postsynaptic density protein-95 (PSD95) plays an important role in cerebral ischaemia injury, but its mechanism needs further research. This study aimed to explore the role of PSD95 in (Ang-(1-7))-Mas-mediated cerebral ischaemia protection and its… read more here.
Keywords: density protein; postsynaptic density; psd95; ang mas ... See more keywords
Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202000945
Abstract: This study proposes a postsynaptic density (PSD) lattice model comprising a non-microtubule tubulin-based backbone structure and its associated proteins, including various PSD scaffold/adaptor proteins and other PSD proteins. A purification protocol was developed to identify… read more here.
Keywords: non microtubule; postsynaptic density; psd; tubulin ... See more keywords