Cholesterol in myasthenia gravis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108788
Abstract: The cholinergic neuromuscular junction is the paradigm peripheral synapse between a motor neuron nerve ending and a skeletal muscle fiber. In vertebrates, acetylcholine is released from the presynaptic site and binds to the nicotinic acetylcholine… read more here.
Keywords: gravis; cholesterol; myasthenia gravis; postsynaptic membrane ... See more keywords
Protein–lipid architecture of a cholinergic postsynaptic membrane
Sign Up to like & getrecommendations! Published in 2020 at "IUCrJ"
DOI: 10.1107/s2052252520009446
Abstract: Cryo-EM reconstruction of the native Torpedo membrane reveals that cholesterol segregates preferentially around nicotinic acetylcholine receptors, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. The microdomains may promote cooperativity between… read more here.
Keywords: architecture cholinergic; protein lipid; cholinergic postsynaptic; membrane ... See more keywords
Contribution of Membrane Lipids to Postsynaptic Protein Organization
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.790773
Abstract: The precise subsynaptic organization of proteins at the postsynaptic membrane controls synaptic transmission. In particular, postsynaptic receptor complexes are concentrated in distinct membrane nanodomains to optimize synaptic signaling. However, despite the clear functional relevance of… read more here.
Keywords: postsynaptic membrane; membrane; contribution; organization ... See more keywords