Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28301-z
Abstract: The pruning of dendritic spines during development requires autophagy. This process is facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that LTD, a fundamental form of synaptic plasticity, also requires autophagy. Here,… read more here.
Keywords: synaptic plasticity; long term; required long; depression ... See more keywords
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00008
Abstract: Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics. Both palmitoylation by palmitoyl acyl transferases (PAT) and depalmitoylation by palmitoyl-protein… read more here.
Keywords: postsynaptic proteins; palmitoylation; role palmitoylation; palmitoylation postsynaptic ... See more keywords